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Reprimo (RPRM) is a potential p53-dependent tumor suppressor gene, which plays an important role in cell cycle arrest at G(2)/M checkpoint. The aim of this study was to characterize RPRM protein expression in breast cancer tissues and its relation with clinic-pathologic features and proliferation...


Buchegger, KurtLopez, JaimeIli, CarmenRiquelme, IsmaelLetelier, PabloGuzman, PabloBellolio, EnriqueCorvalan, Alejandro H.Brebi, PriscillaCarlos Roa, Juan[Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer]Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer

Despite continuous advances in the knowledge of breast cancer pathophysiology, this type of neoplasia remains a leading cause of cancer-related death in women worldwide. Carcinogenesis takes a progressive course from somatic mutations, alteration of the DNA repair mechanisms, inhibition of growth...


Calaf, Gloria M.Zepeda, Andrea B.Castillo, Rodrigo L.Figueroa, Carolina A.Arias, ConsueloFigueroa Villalobos, ElíasFarias, Jorge G.[Molecular aspects of breast cancer resistance to drugs (Review)]Molecular aspects of breast cancer resistance to drugs (Review)

GPER-1 is a novel membrane sited G protein-coupled estrogen receptor. Clinical studies have shown that patients suffering an estrogen receptor alpha (ER alpha)/GPER-1 positive, breast cancer have a lower survival rate than those who have developed ER alpha-positive/GPER-1 negative tumors. Moreove...


Molina, LuisBustamante, FelipeOrtloff Trautmann, AlexanderRamos, IraidiEhrenfeld, PamelaFigueroa, Carlos D.[Continuous Exposure of Breast Cancer Cells to Tamoxifen Upregulates GPER-1 and Increases Cell Proliferation]Continuous Exposure of Breast Cancer Cells to Tamoxifen Upregulates GPER-1 and Increases Cell Proliferation

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