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Introducción: De los pacientes con cáncer, aproximadamente un 20% desarrollan Metástasis Cerebral(MC). La sobrevida estimada sin tratamiento paliativo es de un mes, mientras que con radioterapia paliativa ronda los 3a 8 meses. Objetivo: Realizar una estimación estadística de la sobrevida ...

Background: Schizoaffective disorder, bipolar type (SAD) and bipolar disorder I (BD) present a large clinical overlap. In a 1-year follow-up, we aimed to evaluate days to hospitalization (DTH) and predictors of relapse in a SAD-BD cohort of patients. Methods: A 1-year, prospective, naturalistic c...

Background Dysphagia is associated with aspiration pneumonia after stroke. Data are limited on the influences of dysphagia screen and assessment in clinical practice. Aims To determine associations between a “brief” screen and “detailed” assessment of dysphagia on clinical outcomes in acute stro...

Background: Different techniques have been described for percutaneous Achilles tendon rupture repair, but no biomechanical evaluation has been performed separately for proximal and distal suturing techniques. The purpose of this study was to biomechanically analyze proximal versus distal percutan...

Background: Bronchopulmonary dysplasia (BPD) remains a frequent complication following preterm birth, affecting respiratory health throughout life. Transcriptome analysis in a preterm rabbit model for BPD revealed dysregulation of key genes for inflammation, vascular growth and lung development i...

Background: The potential value of lithium treatment in particular aspects of unipolar major depressive disorder remains uncertain. Methods: With reports of controlled trials identified by systematic searching of Medline, Cochrane Library, and PsycINFO literature databases, we summarized respons...

En Chile, a menudo no se dan las condiciones óptimas para el adecuado cumplimiento del derecho de salud, situación que afecta significativamente la calidad de vida de los inmigrantes. Esto debido, principalmente, a la falta de regularizaciones políticas y a las múltiples barreras,las cu...

In this paper we address the problem of allocating extraction pumps to wells, when exploiting lithium rich brines, as part of the production of lithium salts. The problem of choosing the location of extraction wells is defined using a transportation network structure. Based on the transportation ...

DNA repair defects are inborn errors of immunity that result in increased apoptosis and oncogenesis. DNA Ligase 4-deficient patients suffer from a wide range of clinical manifestations since early in life, including: microcephaly, dysmorphic facial features, growth failure, developmental delay, m...

Type I interferonopathies cover a phenotypically heterogeneous group of rare genetic diseases including the recently described proteasome-associated autoinflammatory syndromes (PRAAS). By definition, PRAAS are caused by inherited and/or de novo loss-of-function mutations in genes encoding proteas...