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Introduction: The evidence on COVID-19 is being produced at high speed, so it is challenging for decision-makers to keep up. It seems appropriate, then, to put into practice a novel approach able to provide the scientific community and other interested parties with quality evidence that is action...


Rada G., GabrielVerdugo-Paiva, FranciscaÁvila, CamilaMorel-Marambio, MacarenaBravo-Jeria, RocíoPesce, FrancoMadrid, EvaIzcovich, Ariel[Síntesis de evidencia relevante para COVID-19 : protocolo común para múltiples revisiones sistemáticas y revisiones panorámicas, Síntesis de evidencia relevante para COVID-19 : protocolo común para múltiples revisiones sistemáticas y revisiones panorámicas][Evidence synthesis relevant to COVID-19 : a protocol for multiple systematic reviews and overviews of systematic reviews]Evidence synthesis relevant to COVID-19 : a protocol for multiple systematic reviews and overviews of systematic reviews

Abstract Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it...


Cruces, PabloRetamal Montes, JaimeHurtado Sepúlveda, DanielErranz, BenjamínIturrieta, PabloGonzález, CarlosDíaz, Franco[A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection]A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Trained immunity is a type of non-specific memory-like immune response induced by some pathogens and vaccines, such as BCG, which can confer antigen-independent protection against a wide variety of pathogens. The BCG vaccine has been extensively used to protect against tuberculosis for almost a 1...


Covián, CamilaRetamal Díaz, Angello RicardoBueno Ramírez, SusanKalergis Parra, Alexis Mikes[Could BCG vaccination induce protective trained immunity for SARS-CoV-2?]Could BCG vaccination induce protective trained immunity for SARS-CoV-2?

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