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Duchene Muscular Dystrophy (DMD) is the most frequent muscular dystrophy and one of the most severe due to the absence of the dystrophin protein. Typical pathological features include muscle weakness, muscle wasting, degeneration, and inflammation. At advanced stages DMD muscles present exacerbat...


Cordova, G.Negroni, E.Cabello-Verrugio, C.Mouly, V.Trollet, C.[Combined therapies for Duchenne muscular dystrophy to optimize treatment efficacy]Combined therapies for Duchenne muscular dystrophy to optimize treatment efficacy

Immobilization is a form of disuse characterized by a loss of strength and muscle mass. Among the main features are decreased IGF-1/Akt signalling and increased ubiquitin-proteasome pathway signalling, which induce greater myosin heavy chain degradation. Activation of the classical renin-angioten...


Morales, M.G.Abrigo, J.Acuna, M.J.Santos, R.A.Bader, M.Brandan, E.Simon, F.Olguin, H.Cabrera, D.Cabello-Verrugio, C.[Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas]Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motoneurons degenerate leading to muscle wasting, paralysis and eventually death from respiratory failure. Several studies indicate that skeletal muscle contributes to disease progression; however th...


Gonzalez, D.Contreras, O.Rebolledo, D.L.Espinoza, J.P.Van Zundert, B.Brandan, E.[ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers]ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers

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