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Grace, DeliaRandolph, Thomas F.Waibel, H.Diall, O.Clausen, P.H.Kamuanga, M.Affognon, Hippolyte D.[Appraisal of policies to promote socially optimal levels of drug resistance]Appraisal of policies to promote socially optimal levels of drug resistance

The Global Forum on Agricultural Research's (GFAR) mission is to mobilize the world scientific community in their effort to alleviate poverty increase food security and promote the sustainable use of natural resources. GFAR plays a role of facilitator between stakeholders, in particular scientist...


Camus, E.McDermott, John J.Francois, T. le[A global initiative on trypanosomosis control: A proposal from the global forum on agricultural research]A global initiative on trypanosomosis control: A proposal from the global forum on agricultural research

Isometamidium chloride is the most important chemoprophylactic agent used in the control of African bovine trypanosomiasis, although breakdowns in prophylaxis have been observed in the field. It is not usually apparent whether these breakdowns are due to inadequate drug dosage regimens, or to the...


Eisler, M.C.Maloo, S.H.Peregrine, A.S.Holmes, P.H.Thorpe, W.R.[Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya]Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya

Isometamidium chloride (Samorin Trypamidium), diminazene aceturate (Berenil, Veriben), homidium chloride (Novidium), homidium bromide (Ethidium) and the salts of quinapyramine (Trypacide, Triquin) are all anti-trypanosomal compounds that are routinely used in domestic livestock. However, the salt...


Peregrine, A.S.Kemei, S.Ndoutamia, G.[Cross-resistance phenotypes associated with induction of resistance to isometamidium chloride and quinapyramine sulphate in Trypanosoma congolense]Cross-resistance phenotypes associated with induction of resistance to isometamidium chloride and quinapyramine sulphate in Trypanosoma congolense

The peri-urban dairy production systems in Uganda, located in the subhumid agro-ecological zone with medium rainfall have a high potential for livestock production (Walsche et al., 1991; Winrock, 1992), but medium tsetse challenge and the associated trypanosomiasis risk may adversely affect dairy...


Patzelt, R.J.Schares, G.Peregrine, A.S.Lessard, P.Laker, C.Leak, S.G.A.Mehlitz, D.[Design of collaborative studies to assess the impact of diseases on production: Case study of trypanosomiasis in peri-urban dairy production systems in Uganda]Design of collaborative studies to assess the impact of diseases on production: Case study of trypanosomiasis in peri-urban dairy production systems in Uganda

Research has been undertaken since 1986 in the Ghibe valley, southwest Ethiopia, monitoring approximately 840 village East African Zebu cattle monthly to assess the effects of trypanosomiasis on productivity. The average monthly trypanosome prevalence between 1986 and 1989 was about 30 percent. M...


Mulatu, W.Rowlands, G.J.D'Ieteren, G.D.M.Nagda, S.M.[Effects of trypanosomiasis on productivity of East African Zebu cattle exposed to drug resistant trypanosomes]Effects of trypanosomiasis on productivity of East African Zebu cattle exposed to drug resistant trypanosomes

Bioassay of acaricide resistance on three common cattle tick species was conducted at the Institute of Agricultural Research, Holetta Research Centre by using standardized FAO Acaricide Resistance Test Methods. Larval progeny of Boophilus decoloratus, Rhipicephalus evertsi evertsi and Amblyomma v...


Shiferaw, Y.Girma, A.Jobre, Y.Hailemariam, M.Zerbini, E.[Bioassay of acaricide resistance on three common cattle tick species around Holetta area]Bioassay of acaricide resistance on three common cattle tick species around Holetta area

Two clones of Trypanosoma (Nannomonas) congolense were derived one from the other by growth in mice and administration of increasing sub-curative doses of isometamidium chloride. One of the clones thus became approximately 10x more tolerant to the trypanocide than the other mRNA from the two clon...


Majiwa, P.A.O.Maina, M.Peregrine, A.S.Kasumba, I.[Comparative molecular analysis of isogenic clones of Trypanosoma (Nanommonas) congolense that differ in their response to isometamidium chloride]Comparative molecular analysis of isogenic clones of Trypanosoma (Nanommonas) congolense that differ in their response to isometamidium chloride

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