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Ottum, Payton A.Arellano, GabrielReyes, Lilian I.Iruretagoyena, MirentxuNaves, Rodrigo[Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation]

A number of studies have shown pharmacologic evidence indicating that stimulation of type I dopamine receptor (DR), favors T-helper-17 (Th17)-mediated immunity involved in experimental autoimmune encephalomyelitis (EAE) and in some other inflammatory disorders. Nevertheless, the lack of drugs tha...


Osorio-Barrios, F.Prado, C.Contreras, F.Pacheco, R.[Dopamine receptor D5 signaling plays a dual role in experimental autoimmune encephalomyelitis potentiating Th17-mediated immunity and favoring suppressive activity of regulatory T-cells]Dopamine receptor D5 signaling plays a dual role in experimental autoimmune encephalomyelitis potentiating Th17-mediated immunity and favoring suppressive activity of regulatory T-cells

The dual potential to promote tolerance or inflammation to self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) in DCs potentiates their inflammatory behaviour, favouring the development of exper...


Prado, C.Gaiazzi, M.González, H.Ugalde, V.Figueroa, A.Osorio-Barrios, F.J.López, E.Lladser, A.Rasini, E.Marino, F.Zaffaroni, M.Cosentino, M.Pacheco, R.[Dopaminergic stimulation of myeloid antigen-presenting cells attenuates signal transducer and activator of transcription 3-activation favouring the development of experimental autoimmune encephalomyelitis]Dopaminergic stimulation of myeloid antigen-presenting cells attenuates signal transducer and activator of transcription 3-activation favouring the development of experimental autoimmune encephalomyelitis

Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experiment...


Haensgen, H.Albornoz, E.Opazo, M.C.Bugueño, K.Jara Fernández, E.L.Binzberger, R.Rivero-Castillo, T.Venegas Salas, L.F.Simon, F.Cabello-Verrugio, C.Elorza, A.A.Kalergis, A.M.Bueno, S.M.Riedel, C.A.[Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis]Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis

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