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Although specific immunoglobulin (Ig) and B cell responses are suppressed during an infection, there is a general activation of the humoral component of the immune system in infections with African trypanosomes. The changes in the humoral immune systems during infections are summarised in this pa...
The target antigens recognized by bovine alloreactive cytotoxic T cells are discussed and compared with serologically defined bovine major histocompatibility complex (MHC) products which make up the bovine lymphocyte antigen (BoLA) system. The role of MHC products in T-cell function in other spe...
The inductive requirements for proliferation of bovine peripheral blood mononuclear cells (PMB) in vitro, in the allogeneic mixed leucocyte reation (MLR), the autologous MLR and the autologous Theileria MLR were compared. In order to examine the role of monocytes in these reactions, methods were...
Contagious bovine pleuropneumonia (CBPP) is one of the most important transboundary animal diseases in Africa. In recent years, CBPP has been found in countries like Botswana from where it was previously eradicated (Amanfu et al., 1998). There is growing evidence to indicate that the incidence of...
This paper determines whether contact between parasite-specific CD4+ T cells and CD8+ T cells is an essential requirement for helper function, additional experiments were performed using two-chamber culture plates incorporating semi-porous membranes. TpM were co-cultured with naive or immune CD8 ...
Techniques for in vivo depletion of lymphocytes using monoclonal antibodies have been well documented for murine systems. This model has played an important role in analysing the involvement of various lymphocyte subsets in several immune mechanisms. In mice 600 ug of Ab are generally injected in...
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