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Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-κB. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate ...


Cabrera, D.Wree, A.Povero, D.Solís, N.Hernandez, A.Pizarro, M.Moshage, H.Torres, J.Feldstein, A.E.Cabello-Verrugio, C.Brandan, E.Barrera, F.Arab, J.P.Arrese, M.[Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis]Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation. Besides, TRPV4 mechano/osmosensitivity depends on phospholipase A2 (PLA2) activation and subsequ...


Berna-Erro, A.Izquierdo-Serra, M.Sepúlveda, R.V.Rubio-Moscardo, F.Doñate-Macián, P.Serra, S.A.Carrillo-Garcia, J.Perálvarez-Marín, A.González-Nilo, F.Fernández-Fernández, J.M.Valverde, M.A.[Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel]Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel

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