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Testing of trypanocidal drug sensitivity in stabilates of pathogenic trypanosomes derived from cattle continues to be problematic, in spite of Development of in vitro techniques, since these are generally complicated and costly for the resources available in developing country laboratories. Furth...


Geerts, S.Ndung'u, J.M.Murilla, G.Mbwambo, H.Sinyangwe, L.Machila, N.Delespaux, V.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.Eisler, M.C.[A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice]A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice
Morrison, W. IvanMurray, M.Roelants, G.E.Mayor-Withey, K.S.Gee, A.L.W. deParis, J.[Susceptibility of inbred strains of mice to African trypanosomiasis]Susceptibility of inbred strains of mice to African trypanosomiasis

Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistanc...


Menge, D.M.Behnke, J.M.Iraqi, F.A.Lowe, A.Teale, A.J.Gibson, John P.Wakelin, D.Baker, R.L.[Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice]Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice

Chemotherapy is the single most important strategy for the control of trypanosomosis in African livestock. Trypanocidal drug resistance is a growing problem across much of sub-Saharan Africa and increasingly recognised as a major threat to livestock production. It is therefore of pressing importa...


Coleman, P.G.Eisler, M.C.McDermott, John J.Murphy, N.B.Majiwa, P.A.O.Peregrine, A.S.[Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense]Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense

C57BL/6J mice are relatively resistant to trypanosomosis compared to BALB/c or A/J mice. Bloodstream trypanosomes are partly dependent on the host for lipid supply and the plasma lipid levels differ between resistant and susceptible mice. Furthermore, genes controlling plasma lipid levels are dif...


Hassan, M.Agaba, MorrisBulimo, WallaceNoyes, H.Brass, A.Hinsley, T.Iraqi, F.A.Kemp, Stephen J.[Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis]Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis
Murray, M.Morrison, W. IvanClifford, D.J.Murray, P.K.McIntyre, W.I.M.[Susceptibility to African trypanosomiasis: Studies in cattle and mice]Susceptibility to African trypanosomiasis: Studies in cattle and mice

Besides the in vitro test, two tests are very commonly used for the detection of trypanocidal drug resistance: the tests in mice and in ruminants. Since it has been shown that several parameters such as the number of trypanosomes inoculated and the time of treatment might influence the outcome of...


Geerts, S.Ndung'u, J.M.Murilla, G.Mbwambo, H.Sirryangwe, L.Machila, N.Delespaux, V.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.Eisler, M.C.[In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants]In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants

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