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During its first two years, the African trypanosome genome project, funded in part by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), has concentrated on three fundamental areas: (1) gene discovery by single-pass sequencing of cDNAs to produce expre...


Melville, S.E.Majiwa, P.A.O.Donelson, J.E.[Resources available from the African Trypanosome Genome Project]Resources available from the African Trypanosome Genome Project

Although common bean (Phaseolus vulgaris) is the most important grain legume in the developing world for human consumption, few genomic resources exist for this species. The objectives of this research were to develop expressed sequence tag (EST) resources for common bean and assess nodule gene e...


Ramírez, M.Graham, MABlanco Lopez, LSilvente, SMedrano Soto, ABlair, Matthew W.Hernández, G.Vance, CPLara, M[Sequencing and analysis of common bean ESTs. Building a foundation for functional genomics]Sequencing and analysis of common bean ESTs. Building a foundation for functional genomics

The pathogenic trypanosomes Trypanosoma vivax and Trypanosoma congolense are transmitted by tsetse and cause trypanosomosis, a debilitating disease affecting livestock in Africa and South America. Here, we discuss the need, relevance and advantage of having the Trypanosoma genomes sequenced, an...


Davila, A.M.R.Majiwa, P.A.O.Grisard, E.C.Aksoy, S.Melville, S.E.[Comparative genomics to uncover the secrets of tsetse and livestock-infective trypanosomes]Comparative genomics to uncover the secrets of tsetse and livestock-infective trypanosomes
Gardner, M.J.Bishop, Richard P.Shah, TushaarVilliers, Etienne P. deCarlton, J.M.Hall, N.Ren, Q.Paulsen, I.T.Pain, A.Berriman, M.Wilson, R.J.M.Sato, S.Ralph, S.A.Mann, D.J.Xiong, Z.Shallom, S.J.Weidman, J.Jiang, L.Lynn,, J.Weaver, B.Shoaibi, A.Domingo, A.R.Wasawo, D.Crabtree, J.Wortman, J.R.Haas, B.Angiuoli, S.V.Creasy, T.H.Lu, C.Suh, B.Silva, J.C.Utterback, T.R.Feldblyum, T.V.Pertea, M.Allen, J.Nierman, W.C.Taracha, E.L.N.Salzberg, S.L.White, O.R.Fitzhugh, H.A.Morzaria, S.P.Venter, J. CraigFraser, C.M.Nene, Vishvanath[Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes]Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes

Heartwater, a tick-borne disease of domestic and wild ruminants, is caused by the intracellular rickettsia Ehrlichia ruminantium (previously known as Cowdria ruminantium). It is a major constraint to livestock production throughout subSaharan Africa, and it threatens to invade the Americas, yet t...


Collins, N.E.Liebenberg, J.Villiers, Etienne P. deBrayton, K.A.Louw, E.Pretorius, A.Faber, F.E.Heerden, H. vanJosemans, A.Kleef, M. vanSteyn, H.C.Strijp, M.F. vanZweygarth, E.Jongejan, F.Maillard, J.C.Berthier, D.Botha, M.Joubert, F.Corton, C.H.Thomson, N.R.Allsopp, M.T.Allsopp, B.A.[The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number]The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number
Denoeud, F.Carretero-Paulet, L.Dereeper, A.Guignon, V.Rouard, M.[The coffee genome provides insight into the convergent evolution of caffeine biosynthesis]The coffee genome provides insight into the convergent evolution of caffeine biosynthesis

International Livestock Research Institute[Mzima livestock project: Transgenic, trypanosome-resistant livestock]Mzima livestock project: Transgenic, trypanosome-resistant livestock

We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatel...


Hernández Valladares, M.Naessens, JanGibson, John P.Musoke, A.J.Nagda, S.M.Rihet, P.Ole-MoiYoi, O.K.Iraqi, F.A.[Confirmation and dissection of QTL controlling resistance to malaria in mice]Confirmation and dissection of QTL controlling resistance to malaria in mice
Williams, R.O.Young, J.R.Majiwa, P.A.O.[Genomic rearrangements correlated with antigenic variation in Trypanosoma brucei]Genomic rearrangements correlated with antigenic variation in Trypanosoma brucei

There have been tremendous advances in our knowledge of trypanosome biology, yet many aspects remain unclear. Currently, the genome of Trypanosome brucei is being sequenced and this, with other genome-wide analysis methods, could provide novel insights into the parasite and facilitate the develop...


Agbo, E.C.Majiwa, P.A.O.Bascher, P.Claassen, E.Marinus, F.W.P.[Trypanosoma brucei genomics and the challenge of identifying drug and vaccine targets]Trypanosoma brucei genomics and the challenge of identifying drug and vaccine targets

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