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A number of studies have shown pharmacologic evidence indicating that stimulation of type I dopamine receptor (DR), favors T-helper-17 (Th17)-mediated immunity involved in experimental autoimmune encephalomyelitis (EAE) and in some other inflammatory disorders. Nevertheless, the lack of drugs tha...


Osorio-Barrios, F.Prado, C.Contreras, F.Pacheco, R.[Dopamine receptor D5 signaling plays a dual role in experimental autoimmune encephalomyelitis potentiating Th17-mediated immunity and favoring suppressive activity of regulatory T-cells]Dopamine receptor D5 signaling plays a dual role in experimental autoimmune encephalomyelitis potentiating Th17-mediated immunity and favoring suppressive activity of regulatory T-cells

The dual potential to promote tolerance or inflammation to self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) in DCs potentiates their inflammatory behaviour, favouring the development of exper...


Prado, C.Gaiazzi, M.González, H.Ugalde, V.Figueroa, A.Osorio-Barrios, F.J.López, E.Lladser, A.Rasini, E.Marino, F.Zaffaroni, M.Cosentino, M.Pacheco, R.[Dopaminergic stimulation of myeloid antigen-presenting cells attenuates signal transducer and activator of transcription 3-activation favouring the development of experimental autoimmune encephalomyelitis]Dopaminergic stimulation of myeloid antigen-presenting cells attenuates signal transducer and activator of transcription 3-activation favouring the development of experimental autoimmune encephalomyelitis

Alteraciones en el desarrollo de la atención y la organización conductual pueden configurar cuadros clínicos como el trastorno déficit de atención (TDA) que puede estar acompañado o no de hiperactividad (TDAH), este último parece tener una relación directa con otros diagnósticos de tipo endocrino...


Torres, M.Bermúdez, V.Ortiz, R.Siguencia, W.Prieto, C.Añez, R.Martínez, M.S.Dávila, L.A.Rojas-Gómez, D.M.Salazar, J.González-Casanova, J.E.Guette, L.S.Guillén-Burgos, H.F.Kusmar, I.Roque, W.Rojas, E.Rojas, J.[FTO gene: Historic background and its relationship with chronic-degenerative diseases][Gene FTO: Aspectos históricos y su relación con enfermedades crónicas no comunicables]Gene FTO: Aspectos históricos y su relación con enfermedades crónicas no comunicables

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