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The polymorphic immunodominant molecule (PIM) of Theileria parva is expressed by the schizont and sporozoite stages of the parasite. We have recently cloned the cDNA encoding the PIM antigen from two stocks of the parasite: the cattle-derived T. parva (Muguga) stock and a buffalo-derived stock. T...


Toye, Philip G.Nyanjui, J.Goddeeris, B.M.Musoke, A.J.[Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva]Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva

Theileria parva, a tick-transmitted protozoan parasite related to Plasmodium spp., causes the disease East Coast fever, an acute and usually fatal lymphoproliferative disorder of cattle in Africa. Previous studies using sera from cattle that have survived infection identified a polymorphic immuno...


Toye, Philip G.Metzelaar, M.J.Wijngaard, P.L.J.Nene, VishvanathIams, K.P.Roose, J.Nyanjui, J.K.Gobright, E.I.Musoke, A.J.Clevers, H.C.[Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva]Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva
Pinder, M.Mayor-Withey, K.S.Roelants, G.E.[Theileria parva parasites transform a subpopulation of T lymphocytes]Theileria parva parasites transform a subpopulation of T lymphocytes

There is strong evidence that class I MHC-restricted parasite-specific CD8+ CTL protect cattle against the protozoan parasite Theileria parva. As part of an effort to develop a subunit vaccine for the induction of these responses, we have investigated the factors involved in the generation of T. ...


Taracha, E.L.N.Awino, EliasMcKeever, Declan J.[Distinct CD4 + T cell helper requirements in Theileria parva-immune and -naive bovine CTL precursors]Distinct CD4 + T cell helper requirements in Theileria parva-immune and -naive bovine CTL precursors
Dobbelaere, D.A.E.Kiarie, J.N.Irvin, A.D.[A rapid method to select Rhipicephalus appendiculatus salivary glands infected with Theileria parva]A rapid method to select Rhipicephalus appendiculatus salivary glands infected with Theileria parva

Compulsory short-interval dipping of cattle for tick control has been enforced in Zimbabwe since the early part of this century. Intensive dipping was initially introduced as a measure to control East Coast fever (ECF), following its introduction from eastern Africa. Dipping was subsequently foun...


Norval, R.A.I.Perry, Brian D.Hargreaves, S.K.[Tick and tick-borne disease control in Zimbabwe: What might the future hold]Tick and tick-borne disease control in Zimbabwe: What might the future hold
Irvin, A.D.Ocama, J.G.R.Spooner, P.R.[Cycle of bovine lymphoblastoid cells parasitized by Theileria parva]Cycle of bovine lymphoblastoid cells parasitized by Theileria parva

Over 500 cattle of all age groups on 2 farms in Zimbabwe were immunised against theileriosis using the "infection and treatment" method and disease prevalence and their productivity assessed during a period of 18 months. The immunising stock, Theileria parva (Boleni) was isolated in Zimbabwe. Non...


Pegram, R.G.James, A.D.Bamhare, C.Dolan, T.T.Hove, T.Kanhai, G.K.Latif, A.A.[Effects of immunisation against Theileria parva on beef cattle productivity and economics of control options]Effects of immunisation against Theileria parva on beef cattle productivity and economics of control options
Brown, W.C.Shaw, M.K.Conrad, P.A.Dolan, T.T.[Theileria-parva: Reappearance of schizonts in infected lymphoblastoid cells treated with parvaquone is dependent on interleukin 2-like growth factors]Theileria-parva: Reappearance of schizonts in infected lymphoblastoid cells treated with parvaquone is dependent on interleukin 2-like growth factors
Morrison, W. IvanBuscher, G.Murray, M.Emery, D.L.Masake, R.A.Cook, R.H.Wells, P.W.[Theileria parva: Kinetics of infection in the lymphoid system of cattle]Theileria parva: Kinetics of infection in the lymphoid system of cattle

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