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Infection with African trypanosomes causes the diseases sleeping sickness in humans and nagana in cattle in sub-Saharan Africa. Suppression of cellular immune responses is a feature of trypanosomiasis in bovine, human, and murine hosts. Some aspects of immunosuppression in the murine model are me...


Taylor, K.Lutje, V.Mertens, B.[Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression]Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression

Theileria parva causes an acute lympho-proliferative disease in cattle, which can result in death of susceptible animals within 2-3 weeks of infection. Analyses of the cellular response in the lymph node draining the site of infection demonstrated an early T cell response, with the appearance of ...


Houston, E.F.Taracha, E.L.N.Brackenbury, L.MacHugh, Niall D.McKeever, Declan J.Charleston, B.Morrison, W. Ivan[Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function]Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function
Nyeko, J.H.P.Ole-MoiYoi, O.K.Majiwa, P.A.O.Otieno, L.H.Ociba, P.M.[Characterization of Trypanosoma isolates from cattle in Uganda using species-specific DNA probes reveals predominace of mixed infection]Characterization of Trypanosoma isolates from cattle in Uganda using species-specific DNA probes reveals predominace of mixed infection
Sileghem, M.R.Flynn, J.N.Saya, R.Williams, D.J.L.[Secretion of co-stimulatory cytokines by monocytes and macrophages during infection with Trypanosoma (Nannomonas) congolense in susceptible and tolerant cattle]Secretion of co-stimulatory cytokines by monocytes and macrophages during infection with Trypanosoma (Nannomonas) congolense in susceptible and tolerant cattle
Buscher, G.Otim, K.[Quantitative studies on Theileria parva in the salivary glands of Rhipicephalus appendiculatus adults: Quantitation and prediction of infection]Quantitative studies on Theileria parva in the salivary glands of Rhipicephalus appendiculatus adults: Quantitation and prediction of infection
Morrison, W. IvanBuscher, G.[The early events of infection with Theileria parva in cattle: Infectivity for cattle of leukocytes incubated in vitro with sporozoites]The early events of infection with Theileria parva in cattle: Infectivity for cattle of leukocytes incubated in vitro with sporozoites
Buscher, G.Morrison, W. IvanNelson, R.T.[Titration in cattle of infectivity and immunogenicity of autologous cell lines infected with Theileria parva]Titration in cattle of infectivity and immunogenicity of autologous cell lines infected with Theileria parva
Koch, H.T.Kambeva, L.Norval, R.A.I.Ocama, J.G.R.Masaka, S.Munatswa, F.C.Honhold, N.Irvin, A.D.[Age resistance to Theileria parva bovis infection in calves]Age resistance to Theileria parva bovis infection in calves
Emery, D.L.[Kinetics of infection with Theileria parva (East Coast fever) in the central lymph of cattle]Kinetics of infection with Theileria parva (East Coast fever) in the central lymph of cattle

Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a role in the host's defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can inf...


Kitani, H.Yagi, Y.Naessens, JanSekikawa, K.Iraqi, F.A.[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene]The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene

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