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Trypanosome infection was detected by the dark ground/phase contrast buffy coat microscopic technique in N'Dama cattle in a high natural tsetse challenge situation in Zaire. The data were used to compare the pattern of infection in very young animals and in their dams, and to evaluate how the pat...
Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a role in the host's defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can inf...
Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative treatment of infected mice for 11 months. This was associated with 3.4-, 33-, and 4.2-fold increases in resistance to diminazene, homidium, and quinapyramine, respectivel...
In order to compare the prophylactic effect provided by a poly(D,L-lactide) sustained-release device (SRD) containing isometamidium (ISMM; Trypamidium) with that provided by the classical im injection of the drug, a field trial was carried out at the Madina Diassa Ranch in Mali, beginning in Nove...
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