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Trypanosomiasis is a serious constraint to livestock production in sub-Saharan Africa. Some breeds of cattle are genetically more resistant to the pathogenic effects of trypanosome infection. We measured B-cell activation and the quantity and isotype of antibody produced at the cellular level in ...


Taylor, K.A.Lutje, V.Kennedy, D.Authié, E.Boulange, A.F.Logan-Henfrey, L.L.Gichuki, B.Gettinby, G.[Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle]Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle

The complete nucleotide sequences were determined for three transcripts each encoding a different variant surface glycoprotein (VSG) of Trypanosoma (Nannomonas) congolense. The nucleotide sequence was determined also for a transcript encoding a fourth VSG, but this was truncated. The data obtaine...


Urakawa, T.Eshita, Y.Majiwa, P.A.O.[The primary structure of Trypanosoma (Nannomonas) congolense variant surface glycoproteins]The primary structure of Trypanosoma (Nannomonas) congolense variant surface glycoproteins

In higher eukaryotes, key steps in the control of growth and proliferation are regulated by protein phosphorylation. However, little is known abot the role of protein phosphorylation in the development cycles of pathogenic protozoa. In Trypanosoma brucei, only the bloodform and procyclic form sta...


Parsons, M.Carter, V.Muthiani, A.Murphy, N.[Trypanosoma congolense: Developmental regulation of protein kinases and tyrosine phosphorylation during the life cycle]Trypanosoma congolense: Developmental regulation of protein kinases and tyrosine phosphorylation during the life cycle

A comparison of T-cell-mediated immune responses in trypanotolerant N'Dama and susceptible Boran cattle during primary infection with tsetse-transmitted Trypanosoma congolense was conducted to assess whether different patterns of T-cell activation occurred during trypanosome infection. Proliferat...


Lutje, V.Taylor, K.A.Kennedy, D.Authié, E.Boulange, A.F.Gettinby, G.[Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection]Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection

T-cell-mediated immune responses to defined antigens of Trypanosoma congolense were measured in cattle undergoing primary infection. The antigens used were the variable surface glycoprotein and two invariant antigens, a 33-kDa cysteine protease (congopain) and a recombinant form of a 69-kDa heat-...


Lutje, V.Mertens, B.Boulange, A.F.Williams, D.J.L.Authié, E.[Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle]Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle
Flynn, J.N.Sileghem, M.R.[The role of the macrophage in induction of immunosuppression in Trypanosoma congolense-infected cattle]The role of the macrophage in induction of immunosuppression in Trypanosoma congolense-infected cattle
Flynn, J.N.Sileghem, M.R.Williams, D.J.L.[Parasite-specific T-Cell response of trypanotolerant and trypanosusceptible cattle during infection with Trypanosoma congolense]Parasite-specific T-Cell response of trypanotolerant and trypanosusceptible cattle during infection with Trypanosoma congolense
Lonsdale-Eccles, J.D.Mpimbaza, G.W.N.Mbawa, Z.M.Kornblatt, J.[Characterisation of the proteases of Trypanosoma congolense and Trypanosoma brucei]Characterisation of the proteases of Trypanosoma congolense and Trypanosoma brucei
Morrison, W. IvanMurray, M.Hinson, C.A.[The response of the murine lymphoid system to a chronic infection with Trypanosoma congolense. 2. The lymph nodes, thymus and liver]The response of the murine lymphoid system to a chronic infection with Trypanosoma congolense. 2. The lymph nodes, thymus and liver

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