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Molyneux, D.H.Floyd, K.Barnish, G.Fèvre, Eric M.[Transmission control and drug resistance in malaria: A crucial interaction]Transmission control and drug resistance in malaria: A crucial interaction

Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the ef...


Hernández Valladares, M.Naessens, JanIraqi, F.A.[Gene-knockout mice in malaria research: Useful or misleading?]Gene-knockout mice in malaria research: Useful or misleading?

Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have i...


Hernández Valladares, M.Naessens, JanIraqi, F.A.[Genetic resistance to malaria in mouse models]Genetic resistance to malaria in mouse models

Background: Plasmodium vivax is the most widespread human malaria parasite. However, genetic information about its pathogenesis is limited at present, due to the lack of a reproducible in vitro cultivation method. Sequencing of the Plasmodium vivax genome suggested the presence of a homolog of de...


Njuguna, J.T.Nassar, M.Hoerauf, A.Kaiser, A.E.[Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax]Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax

We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falc...


Flori, L.Delahaye, N.F.Iraqi, F.A.Hernández Valladares, M.Fumoux, F.Rihet, P.[TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso]TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso

We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatel...


Hernández Valladares, M.Naessens, JanGibson, John P.Musoke, A.J.Nagda, S.M.Rihet, P.Ole-MoiYoi, O.K.Iraqi, F.A.[Confirmation and dissection of QTL controlling resistance to malaria in mice]Confirmation and dissection of QTL controlling resistance to malaria in mice

The aim of the study was to identify entomological determinants of increased malaria transmission in the vicinity of the Koka reservoir in Central Ethiopia. Larval and adult mosquitoes were collected between August 2006 and December 2007 in villages close to (<1 km) and farther away from (>6 km) ...


Kibret, SolomonLautze, JonathanBoelee, ElineMcCartney, Matthew P.[How does an Ethiopian dam increase malaria?: entomological determinants around the Koka Reservoir.]How does an Ethiopian dam increase malaria?: entomological determinants around the Koka Reservoir.

Susceptible A/J and more resistant C57BL/6J mice were infected with Plasmodium chabaudi chabaudi 54X, P.c. chabaudi AS and Plasmodium chabaudi adami 408XZ. As expected, most C57BL/6J mice survived the infections with the different isolates. But in contrast to previous observations, not all A/J ...


Hernández Valladares, M.Naessens, JanNagda, S.M.Musoke, A.J.Rihet, P.Ole-MoiYoi, O.K.Iraqi, F.A.[Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi]Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi

This study compares the effectiveness and cost-effectiveness of indoor residual house-spraying (IRS) and insecticide-treated bednets (ITNs) against infection with Plasmodium falciparum as part of malaria control in the highlands of western Kenya. Homesteads operationally targeted for IRS and ITNs...


Guyatt, H.L.Corlett, S.K.Robinson, Timothy P.Ochola S.A.Snow, R.W.[Malaria prevention in highland Kenya: Indoor residual house-spraying vs. insecticide-treated bednets]Malaria prevention in highland Kenya: Indoor residual house-spraying vs. insecticide-treated bednets

The development of a sterilizing and cost-effective vaccine against malaria remains a major problem despite recent advances. In this study, it is demonstrated that two antigens of P. falciparum UB05, UB09 and their chimera UB05-09 can serve as protective immunity markers by eliciting higher T-cel...


Dinga, J.N.Njimoh, D.L.Kiawa, B.Djikeng, AppolinaireNyasa, R.B.Nkuo-Akenji, T.Pelle, RogerTitanji, V.P.K.[Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria]Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria

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