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In this thesis we present algorithmic and modeling contributions for Stackelberg games that help address challenges due to problem size. Stackelberg games consider that one player, called leader, commits a strategy first and the other player, named follower, observes this strategy and plays a bes...

The general objective of this thesis is to address the problem of forest fires from a pre- ventive perspective, mainly motivated by the increase of this phenomenon worldwide and exacerbated by climate change. The current incidents indicate that preventive policy mea- sures must be taken to reduce...

Plant form is a product of emergent processes of cell division, patterning and morphogenesis. These fundamental processes remain poorly characterised in plants. However, engineering approaches can provide new tools and frameworks for the study and manipulation of plant development. This dissertat...

Foods are complex systems that need to be properly preserved to maintain their quality. Bacteria can alter food and if they are pathogenic, can cause a lot of illness in the consumers. The use of synthetic preservatives is increasingly rejected by consumers due to their side effects. For this rea...

Los alimentos son sistemas complejos que requieren ser conservados adecuadamente para mantener su calidad. Las bacterias alteran los alimentos y si son patógenas, pueden llegar a causar una gran cantidad de enfermedades en los consumidores. El uso de preservantes sintéticos es cada vez más rechaz...

Los materiales de cambio de fase (PCM, por sus siglas en inglés), permiten el almacenamiento de gran cantidad de energía térmica durante el cambio de una fase a otra (generalmente sólido-líquido) a una temperatura específica, presentando alto calor de fusión. Una vez acumulada una cierta cantidad...

La programación de las salas de operaciones (ORs) es una actividad que consiste principalmente en asignar y secuenciar las cirugías en las ORs. Esta actividad es de vital importancia, debido a que las ORs están entre los recursos más caros en hospitales y clínicas. Pero la programación de las ORs...

Operating room (OR) programming is an activity concerning allocation and sequencing of surgeries in the ORs. This activity is of vital importance because ORs are among the most expensive resources in hospitals and clinics. OR programming is difficult because, in addition to the OR itself, each su...

Esta tesis doctoral explora nuevas aristas al problema que enfrenta una compañía cuando debe determinar la composición y precio óptimo para un conjunto de paquetes de productos y/o servicios (bundles) que ofertará en uno o más segmentos de mercado. Se asume inicialmente que los consumidores basa...

Synthetic biology aims to unveil the design principles of complex cellular processes, such as the ones underlying transcriptional networks. An interesting transcriptional genetic module is the Transcriptional-Translational Negative Feedback Loop (TTFL), as find at the heart of circadian clocks. T...

In recent years, freeze concentration (FC) or cryoconcentration has gained great popularity, due to is an emerging and environment friendly concentration technology, since exhibit low energy requirement, high separation and mainly, the process occurs at sub-zero temperatures, allowing to obtain a...