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A marker-assisted introgression (MAI) experiment was conducted to use genetic markers to transfer each of the three trypanotolerance QTL from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. We used a backcross strategy that consisted of selecting two lines, each carrying two of...


Koudande, O.D.Arendonk, Johan A.M. vanIraqi, F.A.[Marker-assisted introgression of trypanotolerance QTL in mice]Marker-assisted introgression of trypanotolerance QTL in mice

It has been reported that some breeds of cattle such as the N'Dama mount a more effective antibody response to the variable surface glycoprotein coat of trypanosomes and that this may contribute to their ability to control the infection. Thus we have investigated antibody responses to surface exp...


Williams, D.J.L.Taylor, K.Newson, J.Gichuki, B.Naessens, Jan[The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance]The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance
Katende, J.Nantulya, V.M.Musoke, A.J.[Comparison between bloodstream and procyclic form trypanosomes for serodiagnosis of African human trypanosomiasis]Comparison between bloodstream and procyclic form trypanosomes for serodiagnosis of African human trypanosomiasis
Murray, M.Murray, P.K.McIntyre, W.I.M.[An improved parasitological technique for the diagnosis of African trypanosomiasis]An improved parasitological technique for the diagnosis of African trypanosomiasis
Stebeck, C.E.Pearson, T.W.[Major surface glycoproteins of procyclic stage African trypanosomes]Major surface glycoproteins of procyclic stage African trypanosomes

In part I of this review of the prospects of vaccination against African trypanosomiasis, contained in the previous issue of World Animal Review, the constraints in developing a vaccine were discussed and current knowledge on the molecular biology of the trypanosome and on antigenic variation wit...


Murray, M.Barry, J.D.Morrison, W. IvanWilliams, R.O.Hirumi, H.Rovis, L.A.[A review of the prospects for vaccination in African trypanosomiasis. Part II]A review of the prospects for vaccination in African trypanosomiasis. Part II

Over a 12-month period 313 (8.4 percent) out of 3727 slaughter cattle sampled at Ibadan abattoir were found to be infected with trypanosomiasis. Infection rates were higher in the dry than in the wet season ranging from 20.4 percent in November to 2.8 percent in May. Overall PCV levels were highe...


Reynolds, L.Opasina, B.A.[Trypanosomes and other blood parasites in slaughter cattle at Ibadan, Nigeria in 1984-1985]Trypanosomes and other blood parasites in slaughter cattle at Ibadan, Nigeria in 1984-1985

Infection with African trypanosomes causes the diseases sleeping sickness in humans and nagana in cattle in sub-Saharan Africa. Suppression of cellular immune responses is a feature of trypanosomiasis in bovine, human, and murine hosts. Some aspects of immunosuppression in the murine model are me...


Taylor, K.Lutje, V.Mertens, B.[Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression]Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression

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