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Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening of gap junction channels permits the diffusional exchange of ions and mol...


Retamal, M.A.García, I.E.Pinto, B.I.Pupo, A.Báez, D.Stehberg, J.Del Rio, R.González, C.[Extracellular cysteine in connexins: Role as redox sensors]Extracellular cysteine in connexins: Role as redox sensors

Connexin (Cx) proteins form hemichannels that a allow bidirectional flow of ions and metabolites between the cytoplasm and extracellular space. Under physiological conditions, hemichannels have a very low probability of opening, but in certain pathologies, hemichannels activity can increase and i...


Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper synaptic transmission and plasticity at the CN...


Under normal conditions, connexin (Cx) hemichannels have a low open probability, which can increase under pathological conditions. Since hemichannels are permeable to relatively large molecules, their exacerbated activity has been linked to cell damage. Cx46 is highly expressed in the lens and it...


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