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Historical and contemporary climate change has impacted Antarctic biota affecting species distribution, demography and connectivity. In Antarctic marine environments, seabirds are important bioindicators of ecological change and can respond to climate change in two main ways: local adaptation or ...

Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder worldwide and has been associated for decades to the Amyloid Precursor Protein (APP), one hallmark in the pathogenesis of AD. However, it is still unclear how APP protein levels are maintained. Increasing eviden...

Miopatía centronuclear (MCN) es una enfermedad dominante y debilitante. Los pacientes con esta patología exhiben una debilidad muscular progresiva que afecta los músculos distales. Varias mutaciones en el gen que codifica para dinamina-2 (Din-2) causan MCN, siendo la mutación más frecuente l...

This thesis is dedicated to the study of differential inclusions involving normal cones of nonregular sets in Hilbert spaces. In particular, we are interested in the sweeping process and its variants. The sweeping process is a constrained differential inclusion involving normal cones which appear...

Chile is the second largest salmon producer worldwide after Norway. This activity is developed mainly in the fjords and channels of the Aysen region, in the south of the country. Importantly, Chile uses 1500 times more antibiotics than Norway to produce one metric ton of salmon. In this study, we...

Chile es uno de los principales productores de salmón a nivel mundial y esta actividad se desarrolla principalmente en el sur del país, particularmente en los fiordos y canales de la Región de Aysén. Uno de los factores asociados a esta actividad es la alta utilización de antibióticos, ya que par...