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Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have i...


Hernández Valladares, M.Naessens, JanIraqi, F.A.[Genetic resistance to malaria in mouse models]Genetic resistance to malaria in mouse models

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...


Iraqi, F.A.Sekikawa, K.Rowlands, G.J.Teale, A.J.[Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection]Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection

African trypansosomes are tsetse-transmitted parasites of chief importance in causing disease in livestock in regions of sub-Saharan Africa. Previous studies have demonstrated that certain breeds of cattle are relatively resistant to infection with trypanosomes, and others are more susceptible. B...


Haas, K.M.Taylor, K.A.MacHugh, Niall D.Kreeger, J.M.Estes, D.M.[Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection]Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection

Parasitic nematodes are among the most common and economically important infectious diseases of grazing livestock, especially in small ruminants in the tropics and subtropics in Kenya the control of gastrointestinal nematode infections in sheep and goats is usually made with synthetic anthelmin...


Githiori, J.B.Hoglund, J.Waller, P.J.Baker, R.L.[Evaluation of anthelmintic properties of extracts from some plants used as livestock dewormers by pastoralist and smallholder farmers in Kenya against Heligmosomoides polygyrus infections in mice]Evaluation of anthelmintic properties of extracts from some plants used as livestock dewormers by pastoralist and smallholder farmers in Kenya against Heligmosomoides polygyrus infections in mice

Albizia anthelmintica Brong., belongs to the plant family Mimosaceae. The plant is widely used in East Africa by poor smallholder farmers and pastoralists to treat their livestock against internal parasites. The anthelmintic effects of water extracts from the bark of A. anthelmintica, obtained f...


Githiori, J.B.Hoglund, J.Waller, P.J.Baker, R.L.[The anthelmintic efficacy of the plant, Albizia anthelmintica, against the nematode parasites Haemonchus contortus of sheep and Heligmosomoides polygyrus of mice]The anthelmintic efficacy of the plant, Albizia anthelmintica, against the nematode parasites Haemonchus contortus of sheep and Heligmosomoides polygyrus of mice

Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...


Behnke, J.M.Mugambi, J.M.M.Clifford, S.Iraqi, F.A.Baker, R.L.Gibson, John P.Wakelin, D.[Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project]Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localization of genes controlling resistance to trypanosomiasis in mice]Localization of genes controlling resistance to trypanosomiasis in mice
Moloo, S.K.[Studies on the transmission of a West African stock of Trypanosoma vivax to rabbits, rats, mice and goats by Glossina morsitans morsitans and G. m. centralis]Studies on the transmission of a West African stock of Trypanosoma vivax to rabbits, rats, mice and goats by Glossina morsitans morsitans and G. m. centralis

In the present study, we used newly developed F11 generation mouse advanced intercross lines (AIL) to fine map Pas1–3 quantitative trait loci (QTL). The (A/J x C57BL/6) F11 AIL mouse population was created by crossing lung tumor-resistant C57BL/6 mice with lung tumor-susceptible A/J mice. By se...


Wang, M.Lemon, W.J.Liu, G.Wang, Y.Iraqi, F.A.Malkinson, A.M.You, M.[Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines]Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines
Autor: Iraqi, F.A.

High-resolution mapping of quantitative trait loci (QTLs) is an essential step towards positional cloning and identification of the corresponding genes. Most QTL detection and mapping studies in mice have been carried out using F2 intercross and backcross populations. As a consequence of the limi...


Iraqi, F.A.[Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes]Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes

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