A first-gneration subunit vaccine for East Coast fever based on the Theileria parva p67 sporozoite surface antigen is entering preliminary field trials. Intensive efforts are also focused on the identification of a schizont-specific omponen for incorporation in a second-generation multi-component...
McKeever, Declan J.
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Morrison, W. Ivan
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[Invited review Novel vaccines against Theileria parva: prospects for sustainability]
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Invited review Novel vaccines against Theileria parva: prospects for sustainability
Full-length recombinant versions of p67, the 709 amino acid major surface protein of Theileria parva sporozoites, induce immunity to East Coast fever (ECF) in cattle. We show that a soluble Escherichia coli recombinant version of p67 (p67635), in which a prokaryotic signal peptide replaces the e...
Bishop, Richard P.
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Nene, Vishvanath
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Staeyert, J.
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Rowlands, G.J.
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Nyanjui, J.
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Osaso, J.
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Morzaria, S.P.
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Musoke, A.J.
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[Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites]
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Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites
Two novel baculovirus-derived recombinant Theileria parva p67 constructs were tested for their vaccine potential against East Coast fever. Boran calves were immunized with a his-GFP-p67 fusion protein (GFP:p67DeltaSS) or with GP64:p67C, a protein fusion between a C-terminal domain of p67 and th...
Heartwater, caused by the rickettsial organism Cowdria ruminantium, is a serious constraint to livestock development in much of sub-Saharan Africa. Traditionally, the disease has been controlled by the use of chemical acaricides to control the vector tick. The University of Florida/USAID-supporte...
Mukhebi, A.W.
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Chamboko, Tafireyi
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O'Callaghan, C.J.
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Peter, T.F.
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Kruska, R.L.
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Medley, G.F.
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Mahan, S.M.
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Perry, Brian D.
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[An assessment of the economic impact of heartwater (Cowdria ruminantium infection) and its control in Zimbabwe]
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An assessment of the economic impact of heartwater (Cowdria ruminantium infection) and its control in Zimbabwe
East Coast fever (ECF) in cattle is caused by the tick-borne protozoan parasite Theileria parva. The major sporozoite surface antigen of T. parva (p67) is an important candidate for inclusion in a subunit vaccine. Recently, we reported the expression and production of different parts of p67 as f...
Schubert, E.
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Sachse, K.
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Jores, Joerg
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Heller, M.
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[Serological testing of cattle experimentally infected with Mycoplasma mycoides subsp. mycoides Small Colony using four different tests reveals a variety of seroconversion patterns]
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Serological testing of cattle experimentally infected with Mycoplasma mycoides subsp. mycoides Small Colony using four different tests reveals a variety of seroconversion patterns
Ole-MoiYoi, O.K.
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Nayar, A.
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Iams, K.P.
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Musoke, A.J.
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Yilma, T.
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[Molecular aspects of Theileria parva and approaches to vaccine development for animals]
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Molecular aspects of Theileria parva and approaches to vaccine development for animals
Tetley, L.
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Vickerman, K.
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Moloo, S.K.
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[Absence of a surface coat from metacyclic Trypanosoma vivax. Possible implications for vaccination against vivax trypanosomiasis]
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Absence of a surface coat from metacyclic Trypanosoma vivax. Possible implications for vaccination against vivax trypanosomiasis
Nene, Vishvanath
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Iams, K.P.
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Gobright, E.I.
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Musoke, A.J.
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[Characterisation of the gene encoding a candidate vaccine antigen of Theileria parva sporozoites]
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Characterisation of the gene encoding a candidate vaccine antigen of Theileria parva sporozoites
This paper reviews the past contributions of epidemiology and economics to the control of tick-borne infections of cattle in Africa. The factors affecting successful and unsuccessful control are evaluated on a gographical and on a production systems basis, with particular reference to Theileria p...
Perry, Brian D.
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Young, A.S.
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[The past and future roles of epidemiology and economics in the control of tick-borne diseases of livestock in Africa: The case of theileriosis]
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The past and future roles of epidemiology and economics in the control of tick-borne diseases of livestock in Africa: The case of theileriosis