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In this chapter we address the puzzle of thermoTRP channel temperature and voltage sensitivity from a biophysical point of view. We deal with the problem through a classic thermodynamic approach, followed by a comparison of thermoTRPs’ behavior with our present knowledge regarding protein structu...

In this chapter we address the puzzle of thermoTRP channel temperature and voltage sensitivity from a biophysical point of view. We deal with the problem through a classic thermodynamic approach, followed by a comparison of thermoTRPs’ behavior with our present knowledge regarding protein structu...

Vitamin C is essential in all mammalian cells. Ascorbic acid (AA) is necessary for the reduction of ferric and cupric ions. Ascorbate is also involved in collagen, steroid and neuropeptide biosynthesis. Furthermore, vitamin C is an aqueous-phase antioxidant concentrated within the cell cytosol an...