Aumentos de Angiotensina II (AngII) plasmática causan Hipertensión Arterial (HTA), inflamación y daño de tejidos blanco. Estudios recientes indican que el sistema inmune participa en la generación del aumento de presión arterial (PA) en respuesta AngII. El suministro de fármacos inmunosupresores ...
High Angiotensin II (AngII) plasma levels cause Hypertension (HBP), inflammation and target tissues damage. Recent studies indicate that the immune system participates in the generation of increased blood pressure (BP) in response to AngII. The administration of immunosuppressive drugs that decre...
Non-alcoholic fatty liver disease (NAFLD), defined as fat accumulation >5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Objective: To identify anthropometric variables d...
Introduction
There is a proved association of mal nutrition in all its forms (obesity, undernutrition and other dietary risks) and climate change (Patterson et al., 2019). In the last report of the Lancet Commissions this concept is defined as “Syndemic” due to the synergy that these three main i...
Bone research in osteoporosis has quite rightly focused on the mineralized component of bone as this is the component that is ultimately responsible for bone strength. However, the non-mineralized component of bone, the bone marrow adipose tissue, is many times more metabolically active and respo...
La investigación en la osteoporosis se ha enfocado con bastante acierto en el componente mineralizado del hueso ya que es el componente que en última instancia es responsable de la fortaleza ósea. Sin embargo, el componente no mineralizado del hueso, es decir, la médula ósea, más específicamente ...
This work includes a review and three studies. The aim of the review carried out has been to compile the available internal methods to assess the individual change from the scores obtained through tests, scales or questionnaires. Initially we have compiled nine of these methods. Then we have inco...
Este trabajo incluye una revisión y tres estudios. El objetivo de la revisión llevada a cabo ha sido el de recopilar los métodos internos disponibles para valorar el cambio individual a partir de las puntuaciones obtenidas mediante test, escalas o cuestionarios. Inicialmente hemos recopilado nuev...
Scientific evidence suggests that the accumulation of α-synuclein (α-syn) protein could contribute to the formation of proteotoxics species, mitochondrial dysfunction and neurodegeneration observed in Parkinson's disease (PD) and other synucleinopathies. Although the exact mechanism of neurotoxic...
Existe evidencia que sugiere que la acumulación de la proteína α-sinucleína (α-syn) podría contribuir a la formación de especies proteotóxicas, a la disfunción mitocondrial y a la neurodegeneración observadas en la enfermedad de Parkinson (EP) y en otras sinucleopatías. Aunque el mecanismo exacto...
La quimiorrecepción central respiratoria es esencial para ajustar la respiración frente a las demandas fisiológicas, y para mantener la homeostasis de PCO2 y pH en el cerebro. Se ha descrito que los astrocitos de la superficie ventral del troncoencéfalo, específicamente en el núcleo retrotrapezoi...
Central respiratory chemoreception is essential to adjust respiration against physiological demands, and to maintain CO2 and pH homeostasis in the brain. Previously, it has been described that astrocytes from the ventral surface of the brainstem, specifically in the retrotrapezoid nucleus, increa...
Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone protein, with many functions such as calcium storage, proper protein folding as well as antiangiogenic and antitumor properties. A wound-healing role for CRT from both human and parasitic origins has been described. However, this funct...
