The existence of intrinsic neuronal activity has been demonstrated at many scales using a variety of methodological approaches, yet its biological relevance is only beginning to be understood. One way to study intrinsic neuronal activity in humans is by using resting-state (RS) functional magneti...
The neuropeptides oxytocin (OT) and vasopressin (AVP) are key regulators of social and emotional behaviors. Accumulating evidence suggesting a role of OT, AVP, and their receptors in the pathophysiology of psychiatric disorders has sparked interest in these systems as therapeutic targets. Nonethe...
Disrupting the neural activity in the left anterior supramarginal gyrus (SMG) or opercular part of the left inferior frontal gyrus (pOp) with repetitive transcranial magnetic stimulation (TMS) has been demonstrated to cause a transient slowing of response times during phonologically more than sem...
Estudios en las últimas décadas han llevado a la conclusión de que no es la cantidad de grasa presente en un individuo, sino su funcionalidad, lo que determina el desarrollo de consecuencias metabólicas y cardiovasculares por sobrepeso y obesidad. La disfunción del tejido adiposo (TA) lleva a la ...
Studies in recent decades have concluded that it is not the amount of fat present in an individual, but its functionality, which determines the development of metabolic and cardiovascular consequences related with overweight and obesity. Adipose tissue (TA) dysfunction leads to the generation of ...
La hipotiroxinemia (HTX) es una condición asintomática frecuente durante el embarazo, la que puede causar alteraciones cognitivas en la progenie. Estudios previos han mostrado que la HTX gestacional acelera el desarrollo de la encefalomielitis autoinmune experimental (EAE) en la progenie, un mode...
Respiratory syncytial virus (RSV) infection is one of the leading causes of infant hospitalization and a major health and economic burden worldwide. Infection with this virus induces an exacerbated innate pro-inflammatory immune response characterized by
La activación del receptor de estrógeno alfa (ERα) por estrógeno (E2) se ha asociado al origen y mantención del cáncer de mama. Sin embargo, los numerosos casos de resistencia al tratamiento con tamoxifeno, han impulsado la búsqueda de nuevas moléculas que tengan incidencia en esta patología. Ent...
The activation of estrogen receptor alpha (ERα) by estrogen (E2) has been associated with the origin and maintenance of breast cancer. However, the numerous cases of tamoxifen resistance have driven the search for new molecules that may have an impact on this neoplasia. Among them, GPR30 (recepto...
La trayectoria de crecimiento intrauterino es un importante indicador de bienestar fetal. El crecimiento fetal está regulado por el estado nutricional y de salud maternos, y adicionalmente por la estructura y función de la placenta, la que permite un adecuado suministro de nutrientes y oxígeno de...
The intrauterine growth trajectory is an important indicator of fetal health. Fetal growth is regulated by the maternal nutritional status and health and by the structure and function of the placenta, which allows an adequate supply of nutrients and oxygen from the mother to fetus. Thus, any dysf...
Pneumocystis es un microhongo extracelular, oportunista y hospedero específico, capaz de producir cuadros de neumonía (PcP) con elevada mortalidad en mamíferos inmunodeprimidos. El tratamiento actual de la infección se basa en eliminar el microorganismo mediante la administración de antibióticos ...
Pneumocystis is an extracellular opportunistic and host-specific microfungus capable of producing pneumonia (PcP) with high mortality rates in immunosuppressed mammals. Current treatment of the infection is based on remove the microorganism using antibiotics such as trimethoprim sulfamethoxazole ...
ABSTRACT
Obesity has turned into a world health burden, and Chile is not an exception. Obesity is a concerning illness not only because of its impact on daily life, but also because it is the root of several diseases. Metabolic dysfunctions are part of these diseases and among them, insulin resi...
