Recent studies describe a new mechanism of intercellular communication mediated by secreted extracellular vesicles (EVs). Exosomes are small EVs (sEVs) released to the extracellular environment by the fusion of the endosomal pathway-related multivesicular bodies (containing intraluminal vesicles)...
Glioblastoma (GBM) corresponde al tipo de tumor primario cerebral más común y agresivo. Aunque GBM cuenta con tratamientos bien establecidos, la sobrevida en Chile de estos pacientes no supera los 6 meses debido a que este tipo de cáncer es altamente quimioresistente. En este tumor se ha descrito...
Glioblastoma (GBM) corresponds to the most common and aggressive type of primary brain tumor. Although GBM has well-established treatments, the survival in Chile of these patients does not exceed 6 months because this type of cancer is highly chemoresistant. In this tumor, the presence of a cell ...
El factor de transcripcion Runx2 controla la expresion transcripcional y la secrecion de moleculas efectoras de la evasion inmune MIC-A y MIC-B. Con es, promueve el desarrollo tumoral por medio de la evasion de la actividad citotoxica de celulas natural killers.
La Esclerosis Lateral Amiotrófica (ELA) es una enfermedad neurodegenerativa en la cual tanto las neuronas motoras superiores e inferiores se degeneran produciendo atrofia muscular, parálisis y muerte debido a fallas respiratorias. Distintos estudios indican que el músculo esquelético contribuye a...
The peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor super-family that regulate the transcription of various enzymes involved in lipid metabolism. Fatty acid synthesis and oxidation, ketogenesis and lipoprotein metabolism are amongst the most important PPAR ...
El lipopolisacárido (LPS) es el mayor componente de la superficie de bacterias Gram negativo y un importante mediador de las interacciones con el hospedero durante el ciclo infeccioso de bacterias patógenas. Tres dominios componen el LPS: el antígeno O (AgO), el core u oligosacárido central y el ...
Lipopolysaccharide (LPS) is the major component of the surface in Gram-negative bacteria and it is an important mediator of the interactions with the host during the infective cycle of pathogenic bacteria. LPS is composed by three domains: O antigen (OAg), core oligosaccharide and lipid A. All LP...
La sobrevida en pacientes con cáncer y sepsis, se asocia directamente a la atrofia muscular (AM). Por ello, caracterizar los eventos involucrados en este fenómeno es de gran interés. En AM inducidas por denervación o glucocorticoides, se ha demostrado que parte importante es consecuencia de la e...
Survival in patients with cancer and sepsis is directly associated with muscle atrophy (MA). Therefore, to characterize the events involved in this phenomenon is of great interest. In MA induced by denervation or glucocorticoids, it has been shown to be important in the expression of hemichannels...
European bees (Apis mellifera) are very important for human activity, but since 2006 there have been high losses of productive colonies. Varroa destructor is considered one of the main culprits, added to other factors such as malnutrition, pesticides and climate change. The objective of this thes...
The axonal region most proximal to soma is the axon initial segment. This region is enriched in voltage-gated sodium channels as well as scaffolding proteins such as ankyrin-G, which allow to this structure to initiate action potentials. As shown in other central neurons, the molecular compositio...
Marine phytoplankton constitute the base of ocean food webs and are responsible for nearly half of the total annual carbon dioxide uptake on the planet acting as important players in biogeochemical cycles. Nitrogen is an essential nutrient that can limit phytoplankton growth. Eukaryotic phytoplan...
