El factor de transcripcion Runx2 controla la expresion transcripcional y la secrecion de moleculas efectoras de la evasion inmune MIC-A y MIC-B. Con es, promueve el desarrollo tumoral por medio de la evasion de la actividad citotoxica de celulas natural killers.
La Esclerosis Lateral Amiotrófica (ELA) es una enfermedad neurodegenerativa en la cual tanto las neuronas motoras superiores e inferiores se degeneran produciendo atrofia muscular, parálisis y muerte debido a fallas respiratorias. Distintos estudios indican que el músculo esquelético contribuye a...
The peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor super-family that regulate the transcription of various enzymes involved in lipid metabolism. Fatty acid synthesis and oxidation, ketogenesis and lipoprotein metabolism are amongst the most important PPAR ...
El lipopolisacárido (LPS) es el mayor componente de la superficie de bacterias Gram negativo y un importante mediador de las interacciones con el hospedero durante el ciclo infeccioso de bacterias patógenas. Tres dominios componen el LPS: el antígeno O (AgO), el core u oligosacárido central y el ...
Lipopolysaccharide (LPS) is the major component of the surface in Gram-negative bacteria and it is an important mediator of the interactions with the host during the infective cycle of pathogenic bacteria. LPS is composed by three domains: O antigen (OAg), core oligosaccharide and lipid A. All LP...
La sobrevida en pacientes con cáncer y sepsis, se asocia directamente a la atrofia muscular (AM). Por ello, caracterizar los eventos involucrados en este fenómeno es de gran interés. En AM inducidas por denervación o glucocorticoides, se ha demostrado que parte importante es consecuencia de la e...
Survival in patients with cancer and sepsis is directly associated with muscle atrophy (MA). Therefore, to characterize the events involved in this phenomenon is of great interest. In MA induced by denervation or glucocorticoids, it has been shown to be important in the expression of hemichannels...
European bees (Apis mellifera) are very important for human activity, but since 2006 there have been high losses of productive colonies. Varroa destructor is considered one of the main culprits, added to other factors such as malnutrition, pesticides and climate change. The objective of this thes...
The axonal region most proximal to soma is the axon initial segment. This region is enriched in voltage-gated sodium channels as well as scaffolding proteins such as ankyrin-G, which allow to this structure to initiate action potentials. As shown in other central neurons, the molecular compositio...
Marine phytoplankton constitute the base of ocean food webs and are responsible for nearly half of the total annual carbon dioxide uptake on the planet acting as important players in biogeochemical cycles. Nitrogen is an essential nutrient that can limit phytoplankton growth. Eukaryotic phytoplan...
The neuromuscular junction (NMJ) is a peripheral cholinergic synapse formed
between a motor axon, a skeletal muscle fiber, and terminal Schwann cells. The
maturation of the NMJ includes a morphological, structural and functional
refinement of this synapse allowing controlled muscle contraction. H...
La unión neuromuscular (UNM) es una sinapsis periférica colinérgica formada
entre un axón motor, una fibra muscular esquelética y células de Schwann
terminales. La maduración de la UNM comprende un refinamiento morfológico,
estructural y funcional de esta sinapsis permitiendo la contracción muscu...
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder worldwide and has been associated for decades to the Amyloid Precursor Protein (APP), one hallmark in the pathogenesis of AD. However, it is still unclear how APP protein levels are maintained. Increasing eviden...
