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Wildebeest-associated malignant catarrhal fever (WA-MCF), a fatal disease of cattle caused by alcelaphine herpesvirus 1 (AlHV-1), is one of the most important seasonal diseases of cattle in wildebeest endemic areas, with annual incidence reaching 10%. Here we report efficacy of over 80% for a vac...


Cook, Elizabeth A.J.Russell, GeorgeGrant, DawnMutisya, Christine N.Omoto, LazarusDobson, ElizabethLankester, FelixNene, Vishvanath[A randomised vaccine field trial in Kenya demonstrates protection against wildebeest-associated malignant catarrhal fever in cattle]A randomised vaccine field trial in Kenya demonstrates protection against wildebeest-associated malignant catarrhal fever in cattle
Autor: Jumba, H.

East Coast fever (ECF) is a current threat to smallholder cattle keepers in the eastern, central, and southern Africa regions; as it causes substantial economic losses. Infection and Treatment Method (ITM) is considered to be the best method for ECF control. ITM has a potential benefit of improvi...


Jumba, H.[Gender perspectives in economic assessment of East Coast Fever vaccination on household welfare among smallholder dairy cattle farmers in Uasin Gishu County, Kenya]Gender perspectives in economic assessment of East Coast Fever vaccination on household welfare among smallholder dairy cattle farmers in Uasin Gishu County, Kenya

East Coast fever (ECF) is a highly fatal lymphoproliferative disease of cattle caused by Theileria parva, a tick-borne intracellular apicomplexan parasite. Parasite antigens that are targets of protective cytotoxic T lymphocyte (CTL) responses are required to formulate a sub-unit vaccine against ...


Akoolo, L.Pelle, RogerSaya, R.Awino, EliasNyanjui, J.Taracha, E.L.N.Kanyari, P.Mwangi, D.M.Graham, S.P.[Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle]Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle
Ayalew, W.Jobre, Y.[Should vaccination be considered as a conservation measure for backyard chicken threatened with highly pathogenic Avian Influenza?]Should vaccination be considered as a conservation measure for backyard chicken threatened with highly pathogenic Avian Influenza?

The ‘Muguga cocktail’ live vaccine, delivered by an infection and treatment protocol, has been widely deployed in Eastern, Central and Southern Africa to protect cattle against East Coast fever, caused by Theileria parva. The vaccine contains 3 component stocks (Muguga, Serengeti-transformed and ...


Oura, C.A.L.Bishop, Richard P.Asiimwe, B.B.Spooner, P.R.Lubega, G.W.Tait, A.[Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field]Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field
Randolph, Thomas F.Ngugi, I.K.Obare, G.A.Kiara, Henry K.Ndung'u, L.W.[An economic assessment of farmer demand in Kenya for a vaccine against East Coast fever]An economic assessment of farmer demand in Kenya for a vaccine against East Coast fever

Bett, Bernard K.[Rift Valley fever in East Africa: Factors driving emergence, potential interventions and challenges to effective control]Rift Valley fever in East Africa: Factors driving emergence, potential interventions and challenges to effective control
O'Callaghan, C.J.Medley, G.F.Kiara, Henry K.McDermott, John J.Musoke, A.J.Morzaria, S.P.Perry, Brian D.[Quantitative analysis of dose-response effects in the transmission dynamics of Theileria parva and the impact of sporozoite-neutralising vaccines]Quantitative analysis of dose-response effects in the transmission dynamics of Theileria parva and the impact of sporozoite-neutralising vaccines
Ndung'u, L.W.Randolph, Thomas F.McDermott, John J.Kiara, Henry K.Perry, Brian D.[Best-bet pathways for the delivery of East Coast fever vaccines to smallholder dairy systems in Kenya]Best-bet pathways for the delivery of East Coast fever vaccines to smallholder dairy systems in Kenya

Theileria are economically important, intra-cellular protozoa, transmitted by ixodid ticks, which infect wild and domestic ruminants. In the mammalian host, parasites infect leukocytes and erythrocytes. In the arthropod vector they develop in gut epithelial cells and salivary glands. All four int...


Bishop, Richard P.Musoke, A.J.Morzaria, S.P.Gardner, M.Nene, Vishvanath[Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks]Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks

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