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To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chrom...


Kemp, Stephen J.Darvasi, A.Soller, M.Teale, A.J.[Genetic control of resistance to trypanosomiasis]Genetic control of resistance to trypanosomiasis

Murine models have suggested that CD8 T cells might play a major parasite-promoting role in African trypanosomiasis. To assess the role of these cells in a natural host environment, we have depleted CD8 cells from Boran cattle in vivo and subsequently infected these animals with Trypanosoma congo...


Sileghem, M.R.Naessens, Jan[Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment?]Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment?

A bioassay was used to measure erythropoietin (EPO) concentrations in calves with haemorrhagic anaemia due to blood loss and in calves with anaemia due to Trypanosoma congolense infection. The bioactivity of EPO was measured in the assay by its stimulatory effect on 125I-deoxyuridine incorporatio...


Buza, J.J.Logan-Henfrey, L.L.Andrianarivo, A.G.Williams, D.J.L.[Rise in erythropoietin concentrations in experimental Trypanosoma congolense infection of calves]Rise in erythropoietin concentrations in experimental Trypanosoma congolense infection of calves

Nuclear extrachromosomal DNA elements have been identified in several kinetoplastids such as Leishmania and Trypanosoma cruzi, but never in Trypanosoma brucei. They can occur naturally or arise spontaneously as the result of sublethal drug exposure of parasites. In most cases, they are represente...


Alsford, N.S.Navarro, M.Jamnadass, Ramni H.Dunbar, H.Ackroyd, M.Murphy, N.B.Gull, K.Ersfeld, K.[The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei]The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei

Inbred strains of laboratory mice exhibit marked differences in survival time following infection with Trypanosoma congolense, the principal cause of trypanosomiasis in African livestock.The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred ...


Clapcott, S.J.Teale, A.J.Kemp, Stephen J.[Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice]Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice

Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differenc...


Naessens, JanTeale, A.J.Sileghem, M.R.[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]Identification of mechanisms of natural resistance to African trypanosomiasis in cattle

It is known that different breeds of cattle display differential susceptibilities to Trypanosome congolense infections, and that N'Dama cattle remain more productive after infection than Boran cattle which are more susceptible to T. congolense. Macrophages from both breeds were cultured in vitro ...


Kazuhiro, Y.Agaba, MorrisIraqi, F.A.Naessens, Jan[Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense]Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense
Fèvre, Eric M.Odiit, M.Coleman, P.G.Woolhouse, Mark E.J.Welburn, S.C.[Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda]Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda

A comparative study on the response of four indigenous cattle breeds of Ethiopia, namely Abigar, Horro, Sheko and Gurage, to natural challenge of trypanosomosis in the Tolley–Gullele area of the Ghibe valley has been undertaken from August 2000 until August 2004. Fifty female yearlings each of Ho...


Lemecha, H.Mulatu, W.Hussein, I.Rege, J.E.O.Tekle, T.Abdicho, S.Ayalew, W.[Response of four indigenous cattle breeds to natural tsetse and trypanosomosis challenge in the Ghibe valley of Ethiopia]Response of four indigenous cattle breeds to natural tsetse and trypanosomosis challenge in the Ghibe valley of Ethiopia
Fèvre, Eric M.Coleman, P.G.Welburn, S.C.Maudlin, I.[Reanalyzing the 1900-1920 sleeping sickness epidemic in Uganda]Reanalyzing the 1900-1920 sleeping sickness epidemic in Uganda

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