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In this paper, available data on the distribution, economic importance and efforts made so far towards the control of Newcastle Disease (ND) in Ethiopia were presented. ND is the single major health constraint, which causes heavy mortality and morbidity to village chicken and affects productivity...


Dessie, TadelleJobre, Y.[A review of the importance and control of Newcastle disease in Ethiopia]A review of the importance and control of Newcastle disease in Ethiopia

Immunity to Theileria parva infection in cattle is often parasite stock specific. The antigenic diversity which is expressed at the schizont stage of the parasite together with a wild reservoir of the organism in buffalo has complicated the development of effective disease control by immunization...


Nene, VishvanathMusoke, A.J.Gobright, E.I.Morzaria, S.P.[Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles]Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles

Studies of the immune responses of cattle to Theileria parva have provided evidence that immunity to the parasite can operate at two levels, namely the sporozoite and the schizont-infected lymphoblast. Antibodies that neutralize the infectivity of sporozoites have been detected in the serum of hy...


Morrison, W. IvanTaracha, E.L.N.McKeever, Declan J.[Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite]Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite

Rift Valley Fever virus (RVFV) causes recurrent outbreaks of acute life-threatening human and livestock illness in Africa and the Arabian Peninsula. No licensed vaccines are currently available for humans and those widely used in livestock have major safety concerns. A ‘One Health’ vaccine develo...


Warimwe, G.M.Gesharisha, J.Carr, B.V.Otieno, S.Otingah, K.Wright, D.Charleston, B.Okoth, Edward A.Elena, L.G.Lorenzo, G.Ayman, E.B.Alharbi, N.K.Al-Dubaib, M.A.Brun, A.Gilbert, S.C.Nene, VishvanathHill, A.V.S.[Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever]Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever

To identify the genes encoding novel immunodominant antigens of Theileria parvo a ?gt11 library of piroplasm genomic DNA was immunoscreened with bovine recovery serum and a gene encoding a 150 kDa antigen (p150) was identified. The predicted polypeptide contains an N-terminal secretory signal seq...


Skilton, Robert A.Bishop, Richard P.Wells, C.W.Spooner, P.R.Gobright, E.I.Nkonge, C.Musoke, A.J.Macklin, M.D.Iams, K.P.[Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)]Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)

We describe the development of TparvaDB, a comprehensive resource to facilitate research towards development of an East Coast fever vaccine, by providing an integrated user-friendly database of all genome and related data currently available for Theileria parva. TparvaDB is based on the Generic M...


Visendi, P.Ng'ang'a, W.Bulimo, WallaceBishop, Richard P.Ochanda, J.Villiers, Etienne P. de[TparvaDB: A database to support Theileria parva vaccine development]TparvaDB: A database to support Theileria parva vaccine development

The eradication of smallpox (variola) and the subsequent cessation of routine vaccination have left modern society vulnerable to bioterrorism employing this devastating contagious disease. The existing, licensed vaccines based on live vaccinia virus (VACV) are contraindicated for a substantial nu...


Lantto, J.Hansen, M.H.Rasmussen, S.K.Steinaa, LucillaPoulsen, T.R.Duggan, J.Dennis, M.Naylor, I.Easterbrook, L.Bregenholt, S.Haurum, J.Jensen, A.[Capturing the natural diversity of the human antibody response against vaccinia virus]Capturing the natural diversity of the human antibody response against vaccinia virus

The major sporozoite surface antigen of Theileria annulata (SPAG-1) is a candidate for inclusion in a subunit vaccine. In this paper we summarize the results of 4 vaccination experiments using recombinant SPAG-1 expressed in different systems and presented in different adjuvants. The antigen has ...


Boulter, N.Brown, D.Wilkie, G.Williamson, S.Kirvar, E.Knight, P.Glass, E.Campbell, J.Morzaria, S.P.Nene, VishvanathMusoke, A.J.Oliveria, C. deGubbels, M.J.Jongejan, F.Hall, R.[Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems]Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems

The development of a sterilizing and cost-effective vaccine against malaria remains a major problem despite recent advances. In this study, it is demonstrated that two antigens of P. falciparum UB05, UB09 and their chimera UB05-09 can serve as protective immunity markers by eliciting higher T-cel...


Dinga, J.N.Njimoh, D.L.Kiawa, B.Djikeng, AppolinaireNyasa, R.B.Nkuo-Akenji, T.Pelle, RogerTitanji, V.P.K.[Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria]Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria

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