The passive transfer of antibodies from dams to offspring via colostrum is believed to play an important role in protecting neonatal mammals from infectious disease. The study presented here investigates the uptake of colostrum by 548 calves in western Kenya maintained under smallholder farming, ...
Toye, Philip G.
,
Handel, I.
,
Gray, J.
,
Kiara, Henry K.
,
Thumbi, S.M.
,
Jennings, A.
,
Wyk, I.C. van
,
Ndila, M.
,
Hanotte, Olivier H.
,
Coetzer, K.
,
Woolhouse, Mark E.J.
,
Bronsvoort, B.M. de C.
,
[Maternal antibody uptake, duration and influence on survival and growth rate in a cohort of indigenous calves in a smallholder farming system in western Kenya]
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Maternal antibody uptake, duration and influence on survival and growth rate in a cohort of indigenous calves in a smallholder farming system in western Kenya
The membrane-associated enzyme l-α-glycerol-3-phosphate oxidase (GlpO) of Mycoplasma mycoides subs. mycoides (Mmm), the causal agent of contagious bovine pleuropneumonia (CBPP) has been identified as a virulence factor responsible for the release of toxic by-products such as H2O2 that mediate hos...
Mulongo, M.M.
,
Frey, J.
,
Smith, K.
,
Schnier, C.
,
Wesonga, H.O.
,
Naessens, Jan
,
McKeever, Declan J.
,
[Cattle immunized against the pathogenic l-α-glycerol-3-phosphate oxidase of Mycoplasma mycoides subs. mycoides in cattle fail to generate neutralizing antibodies and succumb to disease on challenge]
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Cattle immunized against the pathogenic l-α-glycerol-3-phosphate oxidase of Mycoplasma mycoides subs. mycoides in cattle fail to generate neutralizing antibodies and succumb to disease on challenge
The accurate estimation of livestock weights is important for many aspects of livestock management including nutrition, production and appropriate dosing of pharmaceuticals. Subtherapeutic dosing has been shown to accelerate pathogen resistance which can have subsequent widespread impacts. There ...
Lesosky, M.
,
Dumas, S.
,
Conradie, I.
,
Handel, I.G.
,
Jennings, A.
,
Thumbi, S.M.
,
Toye, Philip G.
,
Bronsvoort, B.M. de C.
,
[A live weight-heart girth relationship for accurate dosing of east African shorthorn zebu cattle]
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A live weight-heart girth relationship for accurate dosing of east African shorthorn zebu cattle
The protozoan parasite Theileria parva causes a usually fatal disease in cattle, known as East Coast fever. Cattle can be vaccinated by injecting live parasites simultaneously with long acting oxytetracycline (the Infection and Treatment Method, ITM). The immunity induced by ITM is believed to be...
Steinaa, Lucilla
,
Saya, R.
,
Awino, Elias
,
Toye, Philip G.
,
[Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen]
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Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen
As it feeds upon cattle, Rhipicephalus (Boophilus) microplus is capable of transmitting a number of pathogenic organisms, including the apicomplexan hemoparasite Babesia bovis, a causative agent of bovine babesiosis. The R. microplus female gut transcriptome was studied for two cohorts: adult fem...
Current contagious bovine pleuropneumonia (CBPP) vaccines are based on live-attenuated strains of Mycoplasma mycoides subsp. mycoides (Mmm). These vaccines have shortcomings in terms of efficacy, duration of immunity and in some cases show severe side effects at the inoculation site; hence the ne...
Pérez Casal, J.
,
Prysliak, T.
,
Maina, T.
,
Wang, Y.
,
Townsend, H.
,
Berverov, E.
,
Nkando, I.
,
Wesonga, H.O.
,
Liljander, Anne M.
,
Jores, Joerg
,
Naessens, Jan
,
Gerdts, V.
,
Potter, A.
,
[Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia]
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Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia
Waithanji, Elizabeth M.
,
Mtimet, Nadhem
,
Muindi, P.
,
[Contagious bovine pleuropneumonia vaccine delivery and adoption by women and men in North-Eastern Kenya]
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Contagious bovine pleuropneumonia vaccine delivery and adoption by women and men in North-Eastern Kenya
Respiratory failure and death in East Coast Fever (ECF), a clinical syndrome of African cattle caused by the apicomplexan parasite Theileria parva, has historically been attributed to pulmonary infiltration by infected lymphocytes. However, immunohistochemical staining of tissue from T. parva inf...
Fry, Lindsay M.
,
Schneider, D.A.
,
Frevert, C.W.
,
Nelson, D.D.
,
Morrison, W. Ivan
,
Knowles, Donald P.
,
[East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure]
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East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure
Mungube, E.O.
,
Diall, O.
,
Baumann, M.P.O.
,
Hoppenheit, A.
,
Hinney, B.
,
Bauer, B.
,
Sanogo, Y.
,
Maiga, B.
,
Zessin, K.H.
,
Randolph, Thomas F.
,
Clausen, P.H.
,
[Best-bet integrated strategies for containing drug-resistant trypanosomes in cattle]
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Best-bet integrated strategies for containing drug-resistant trypanosomes in cattle
Contagious Bovine Pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides, is widespread in sub-Saharan Africa. The current live vaccine T1/44 has limited efficacy and occasionally leads to severe side effects in the animals. A better understanding of the immune responses triggered ...
Sacchini, F.
,
Luciani, M.
,
Salini, R.
,
Scacchia, M.
,
Pini, A.
,
Lelli, R.
,
Naessens, Jan
,
Poole, Elizabeth J.
,
Jores, Joerg
,
[Plasma levels of TNF-α, IFN-γ, IL-4 and IL-10 during a course of experimental contagious bovine pleuropneumonia]
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Plasma levels of TNF-α, IFN-γ, IL-4 and IL-10 during a course of experimental contagious bovine pleuropneumonia