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Mwamachi, D.Irvin, A.D.Ong'are, J.O.[Chemotherapy of East Coast fever in cattle infected with isolates of Theileria parva from coast province]Chemotherapy of East Coast fever in cattle infected with isolates of Theileria parva from coast province

Species: RuminantsTheileria parva is an intracellular protozoal parasite which causes East Coast Fever (ECF), a major constraint to cattle production in eastern and southern Africa. Characteristics of the protective CD8+ T-cell response against T. parva suggest it is focused on a limited number o...


Connelley, T.MacHugh, Niall D.Graham, S.Taracha, E.A.Burrells, A.Ngugi, D.Morrison, W. Ivan[The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality]The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality

Theileria parva is the etiologic agent of East Coast fever, an economically important disease of cattle in sub-Saharan Africa. This protozoan parasite is biologically transmitted by Rhipicephalus appendiculatus (Neumann) (Acari: Ixodidae). An understanding of the vector—parasite interaction may a...


Odongo, David O.Ueti, M.W.Mwaura, S.N.Knowles, Donald P.Bishop, Richard P.Scoles, Glen A.[Quantification of Theileria parva in Rhipicephalus appendiculatus (Acari: Ixodidae) Confirms differences in infection between selected tick strains]Quantification of Theileria parva in Rhipicephalus appendiculatus (Acari: Ixodidae) Confirms differences in infection between selected tick strains

Theileria parva is a tick-transmitted protozoan parasite that infects and transforms bovine lymphocytes. We have previously shown that Theileria parva Chitongo is an isolate with a lower virulence than that of T. parva Muguga. Lower virulence appeared to be correlated with a delayed onset of the ...


Tindih, H.S.Geysen, D.Goddeeris, B.M.Awino, EliasDobbelaere, D.A.E.Naessens, Jan[A Theileria parva isolate of low virulence infects a subpopulation of lymphocytes]A Theileria parva isolate of low virulence infects a subpopulation of lymphocytes

An in vitro infectivity assay was used to examine five cryoprotectants for their suitability of preserving Theileria parva sporozoites. All five were capable of preserving T. parva sporozoites through freezing, the optimal concentrations being 7.5 percent for glycerol, 5 percent for dimethyl sulp...


Kimbita, E.N.Silayo, R.S.Jolan, T.T.[Comparison of cryoprotectants in the preservation of Theileria parva sporozoites using in vitro infectivity assay]Comparison of cryoprotectants in the preservation of Theileria parva sporozoites using in vitro infectivity assay

Polymorphic, multicopy gene families are frequently located in subtelomeric regions of the genomes of parasitic protozoa. Theileria parva telomere-associated (TA) DNA from two chromosomes contained long open reading frames (ORFs) 54% identical at the N-termini whose ends were 2670 and 2680 bp fro...


Bishop, Richard P.Gobright, E.I.Nene, VishvanathMorzaria, S.P.Musoke, A.J.Sohanpal, B.K.[Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres]Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres

Theileria are economically important, intra-cellular protozoa, transmitted by ixodid ticks, which infect wild and domestic ruminants. In the mammalian host, parasites infect leukocytes and erythrocytes. In the arthropod vector they develop in gut epithelial cells and salivary glands. All four int...


Bishop, Richard P.Musoke, A.J.Morzaria, S.P.Gardner, M.Nene, Vishvanath[Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks]Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks

The presence of the schizont stage of the obligate intracellular parasites Theileria parva or T. annulata in the cytoplasm of an infected leukocyte results in host cell transformation via a mechanism that has not yet been elucidated. Proteins, secreted by the schizont, or expressed on its surface...


Casanova, C.L.Xue, G.Taracha, E.L.N.Dobbelaere, D.A.E.[Post-translational signal peptide cleavage controls differential epitope recognition in the QP-rich domain of recombinant Theileria parva PIM]Post-translational signal peptide cleavage controls differential epitope recognition in the QP-rich domain of recombinant Theileria parva PIM

As a first step in developing compartment-specific markers for protein trafficking within Theileria parva, we have isolated cDNAs encoding homologues of the small GTP binding proteins Rab1 and Rab4. The T. parva homologue of Rab1 (TpRab1), a protein which regulates vesicular transport between the...


Janoo, R.T.K.Musoke, A.J.Wells, C.Bishop, Richard P.[A Rab1 homologue with a novel isoprenylation signal provides insight into the secretory pathway of Theileria parva]A Rab1 homologue with a novel isoprenylation signal provides insight into the secretory pathway of Theileria parva

East coast fever (ECF) is a major tick-borne disease caused by the apicomplexan parasite Theileria parva (1). ECF is an acute leukemia-like disease of cattle that is endemic in eastern, central and souther Africa, where it is responsible for significant mortality and losses in animal production. ...


Grab, D.J.Naessens, JanOle-MoiYoi, O.K.[Evidence for ADP-ribosylation and G protein in Theileria parva-transformed bovine lymphocytes]Evidence for ADP-ribosylation and G protein in Theileria parva-transformed bovine lymphocytes

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