The membrane-associated form of the variable surface glycoprotein (mfVSG) from African trypanosomes is a potent macrophage activator capable of inducing production of tumor necrosis factor z (TNFalfa) in both bovine and murine models. Using a bovine model. we have re-investigated the hypothesis t...
Sileghem, M.R.
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Saya, R.
,
Grab, D.J.
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Naessens, Jan
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[An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes]
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An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes
Susceptibility of African buffalo, eland, waterbuck, N'Dama and Boran cattle to sequential Glossina morsitans centralis-transmitted infections of Trypanosoma congolense, T. brucei brucei and T. vivax was compared, and their possible role as reservoirs of these parasites for G. moristans centralis...
Moloo, S.K.
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Orinda, G.O.
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Sabwa, C.L.
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Minja, S.H.
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Masake, R.A.
,
[Study on the sequential tsetse-transmitted Trypanosoma congolense, T. brucei brucei and T. vivax infections to African buffalo, eland, waterbuck, N'Dama and Boran cattle]
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Study on the sequential tsetse-transmitted Trypanosoma congolense, T. brucei brucei and T. vivax infections to African buffalo, eland, waterbuck, N'Dama and Boran cattle
Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production ...
Trypanosomes have no de novo purine biosynthesis and thus depend upon salvage pathways to obtain purines for their metabolic pathways and for the biosynthesis of nucleic acids. An inosine-adenosine-guanosine preferring nucleoside hydrolase (IAG-nucleoside hydrolase) from the African trypanosome T...
Webster, P.
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Russo, D.C.W.
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Black, S.J.
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[The interaction of Trypanosoma brucei with antibodies to variant surface glycoproteins]
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The interaction of Trypanosoma brucei with antibodies to variant surface glycoproteins
Webster, P.
,
Grab, D.J.
,
[Intracellular localization of variant surface glycoprotein and transferrin-gold in Trypanosoma brucei]
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Intracellular localization of variant surface glycoprotein and transferrin-gold in Trypanosoma brucei
N-Ribohydrolases, including the inosine-adenosine-guanosine-preferring (IAG) nucleoside hydrolase, have been proposed to be involved in the nucleoside salvage pathway of protozoan parasites and may consitute rational therapeutic targets for the treatment of these diseases. Reported is the complet...
Pelle, Roger
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Schramm, V.L.
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Parkin, D.W.
,
[Molecular cloning and expression of a purine-specific N-ribohydrolase from Trypanosoma brucei brucei. Sequence expression and molecular analysis]
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Molecular cloning and expression of a purine-specific N-ribohydrolase from Trypanosoma brucei brucei. Sequence expression and molecular analysis
Bulow, R.
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Griffiths, G.
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Webster, P.
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Stiernof, Y.
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Opperdoes, F.R.
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Overath, P.
,
[Intracellular localization of the glycosylphosphatidylinositol-specific phospholipase C of Trypanosoma brucei]
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Intracellular localization of the glycosylphosphatidylinositol-specific phospholipase C of Trypanosoma brucei
Following an outbreak of trypanosomosis in horses on a farm in Kenya, 18 trypanosome isolates were collected from the infected animals over a period of one and a half years and cryopreserved for characterization. The characterization was done on the basis of morphology using Giemsa-stained blood ...
Kihurani, D.O.
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Masake, R.A.
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Nantulya, V.M.
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Mbiuki, S.M.
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[Characterization of trypanosome isolates from naturally infected horses on a farm in Kenya]
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Characterization of trypanosome isolates from naturally infected horses on a farm in Kenya
Teneral tsetse flies infected with either Trvpanosoma brucei or T. vivax were fed on healthy cattle. Blood samples collected daily from the cattle were examined by microscopy for the presence of trypanosomes, in thick smear, thin smear and in the buffy coat (BC). All the cattle fed upon by infect...
Masake, R.A.
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Njuguna, J.T.
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Brown, C.C.
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Majiwa, P.A.O.
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[The application of PCR-ELISA to the detection of Trypanosoma brucei and T. vivax infections in livestock]
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The application of PCR-ELISA to the detection of Trypanosoma brucei and T. vivax infections in livestock