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The review discusses the current field status of human and bovine trypanosomiases, and focuses on the molecular basis of innate and acquired control of African trypanosomes in people, cattle and Cape buffalo


Black, S.J.Seed, J.R.Murphy, N.B.[Innate and acquired resistance to African trypanosomiasis]Innate and acquired resistance to African trypanosomiasis

A household survey was conducted in six villages of Busia District, Kenya, to assess people's willingness to contribute labor and money to control the tsetse flies that transmit trypanosomiasis. A Heckman's two-step model was estimated to identify factors affecting the probability that a responde...


Echessah, P.N.Swallow, B.M.Kamara, D.W.Curry, J.J.[Willingness to contribute labor and money to tsetse control: application of contingent valuation in Busia District, Kenya]Willingness to contribute labor and money to tsetse control: application of contingent valuation in Busia District, Kenya

A visually read dot-enzyme linked immunosorbent asay (dot-ELISA) developed for the detection of trypanosomes in tsetse flies (Glossina spp.) was evaluated in the laboratory and under field conditions. In the evaluation, the fly dissection method was used as a standard technique and compared to th...


Ouma, J.O.Masake, R.A.Masiga, Daniel K.Moloo, S.K.Njuguna, J.T.Ndung'u, J.M.[Comparative sensitivity of dot-ELISA, PCR and dissection method for the detection of trypanosome infections in tsetse flies (Diptera: Glossinidae)]Comparative sensitivity of dot-ELISA, PCR and dissection method for the detection of trypanosome infections in tsetse flies (Diptera: Glossinidae)

Cattle from 50 farms in Mukono County, Uganda, were monitored for trypanosomes every second month over an 18-month period (1995–1996) by mini-anion exchange chromatography and haematocrit centrifugation techniques. Eighteen trypanosome isolates collected from cattle during this period were charac...


Olila, D.McDermott, John J.Eisler, M.C.Mitema, E.S.Patzelt, R.J.Clausen, P.H.Poetzsch, C.J.Zessin, K.H.Mehlitz, D.Peregrine, A.S.[Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda]Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda

Sequential biopsies of sternal bone marrow (BM) of three trypanosusceptible Boran and three trypanotolerant N'Dama cattle were examined by light and transmission electron microscopy before and up to 112 days postinfection (DPI) with Trypanosoma congolense. Before infection, the percentage of cell...


Anosa, V.O.Logan-Henfrey, L.L.Wells, C.W.[The role of the bone marrow in bovine trypanotolerance. II. Macrophage function in Trypanosoma congolense - infected cattle]The role of the bone marrow in bovine trypanotolerance. II. Macrophage function in Trypanosoma congolense - infected cattle

A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...


Koudande, O.D.Thomson, P.C.Bovenhuis, H.Iraqi, F.A.Gibson, John P.Arendonk, Johan A.M. van[Biphasic survival analysis of trypanotolerance QTL in mice]Biphasic survival analysis of trypanotolerance QTL in mice

A framework for assessing the integrated impacts of trypanosomiasis interventions that resembles the structure of the DPSIR conceptual model (see EEA 2000) is developed in this study. This framework provides a way to make evident the pressures on the involved systems, define the target groups and...


Rodríguez, L.C.Kshatriya, MrigeshMugatha, Simon M.Maitima, J.M.[A conceptual framework for integrated impact assessment of trypanosomiasis interventions]A conceptual framework for integrated impact assessment of trypanosomiasis interventions

Approximately 390 East African Zebu calves from birth to 3 years of age and their dams were monitored monthly from 1986 to 1992 in nine village herds in an area of high trypanosomiasis risk in southwest Ethiopia where there was resistance to all available trypanocidal drugs. Cattle were individua...


Rowlands, G.J.Mulatu, W.Authié, E.D'Ieteren, G.D.M.Leak, S.G.A.Nagda, S.M.[Effects of trypanosomiasis on growth and mortality of young East African Zebu cattle exposed to drug-resistant trypanosomes]Effects of trypanosomiasis on growth and mortality of young East African Zebu cattle exposed to drug-resistant trypanosomes

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