West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitae...
Naessens, Jan
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Leak, S.G.A.
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Kennedy, D.J.
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Kemp, Stephen J.
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Teale, A.J.
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[Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]
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Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense
Three international workshops held over the past eight years have addressed the identification and nomenclature of leukocyte differentiation antigens in ruminants. This article explains the progress the workshops have made.
Naessens, Jan
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Howard, C.J.
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Hopkins, J.
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[Nomenclature and characterization of leukocyte differentiation antigens in ruminants]
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Nomenclature and characterization of leukocyte differentiation antigens in ruminants
The first visible response in livestock to the bite of a trypanosome-infected tsetse fly is the formation of a localized skin reaction, also known as a chancre. This is an inflammatory response in the skin associated with swelling and an influx of cells. It is thought to be associated with an a...
Naessens, Jan
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Mwangi, D.M.
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Buza, J.
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Moloo, S.K.
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[Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes]
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Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes
Naessens, Jan
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Newson, J.
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Bensaid, A.
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Teale, A.J.
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Magondu, J.
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Black, S.J.
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[De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle]
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De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle
Trypanotolerance is the capacity of certain West-African, taurine breeds of cattle to remain productive and gain weight after trypanosome infection. Laboratory studies, comparing Trypanosoma congolense infections in trypanotolerant N'Dama cattle (Bos taurus) and in more susceptible Boran cattle (...
Naessens, Jan
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[Bovine trypanotolerance: a natural ability to prevent severe anaemia and haemophagocytic syndrome?]
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Bovine trypanotolerance: a natural ability to prevent severe anaemia and haemophagocytic syndrome?
IgD, first demonstrated in humans, has been unequivocally shown to exist in primates and rodents. In addition to lgM a second unique membrane isotype, generally considered to be lgD, has been demonstrated in a number of other species, including dogs and chickens. Because of its assumed widespread...
Conditions were established to obtain depletion of T lymphocyte subsets in lymphoid tissues of calves by injection of mouse monoclonal antibodies to T cell antigens. Adverse reactions were avoided by injecting small quantities of antibody until target cells had disappeared from blood. Two differe...
Naessens, Jan
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Scheerlinck, J.P.
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Buysscher, E.V. de
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Kennedy, D.
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Sileghem, M.R.
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[Effective in vivo depletion of T cell subpopulations and loss of memory cells in cattle using mouse monoclonal antibodies]
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Effective in vivo depletion of T cell subpopulations and loss of memory cells in cattle using mouse monoclonal antibodies
Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differen...
Naessens, Jan
,
Teale, A.J.
,
Sileghem, M.R.
,
[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]
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Identification of mechanisms of natural resistance to African trypanosomiasis in cattle
Naessens, Jan
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Sileghem, M.R.
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MacHugh, Niall D.
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Park, Y.H.
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Davis, W.C.
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Toye, Philip G.
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[Selection of BoCD25 monoclonal antibodies by screening mouse L cells transfected with the bovine p55-interleukin-2 (IL-2) receptor gene]
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Selection of BoCD25 monoclonal antibodies by screening mouse L cells transfected with the bovine p55-interleukin-2 (IL-2) receptor gene