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Este proyecto propone producir nuevos fármacos para el tratamiento de cánceres cuya malignidad es producto de alteraciones cancerigénicas del receptor del factor de crecimiento epidérmico (EGFR). 40-50% de los cánceres sólidos presentan alteraciones oncog


ABSTRACT Obesity has turned into a world health burden, and Chile is not an exception. Obesity is a concerning illness not only because of its impact on daily life, but also because it is the root of several diseases. Metabolic dysfunctions are part of these diseases and among them, insulin resi...


Effector CD8+ cytotoxic T lymphocytes (CTLs) contribute significantly to tumoral immunity and can recognize and kill tumor cells by means of secretion cytotoxic granules and cytokines, such as and IFN-γ. CTL activation requires specific recognition of ant


Las enfermedades autoinmunes, como el Lupus Eritematoso Sistémico (LES), ocurren por defectos en los mecanismos de regulación del sistema inmunológico. Aunque la etiopatogenia de esta enfermedad es desconocida aún, se cree que la susceptibilidad de cada i


Objective: Post-stroke Aphasia is a devastating condition associated with increased risk of depression and other comorbidities. It leads to long-term disability and a high number of patients are not able to return to work. There is an urgent need for better therapeutic interventions as well as ou...


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