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When propagated in vitro bloodstream forms of all Trypanosoma brucei subspecies give suspension cultures while T Congolense gives predominantly adherent ones. As a result, in vitro assays used in assessing drug sensitivity in T brucei species are unsuitable for T congolense unless a laborious ste...

The African trypanosomiases constitute a multifaceted medical-veterinary-economic problem of vector-borne human and livestock diseases (157, 416) which pose a great menace to human life and needs. Over 500 million ac r es of fertile but tsetseinfested land for settlement, agriculture, livestock, ...

The African trypanosomiases constitute a multifaceted medical-veterinary-economic problem of vector-borne human and livestock diseases (157, 416) which pose a great menace to human life and needs. Over 500 million ac r es of fertile but tsetseinfested land for settlement, agriculture, livestock, ...

The advances in genomics technologies and genome analysis methods that offer new leads for accelerating discovery of putative targets for developing overall control tools are reviewed in Chapter 1. In Chapter 2, a PCR typing method based on restriction fragment length polymorphism analysis of the...

In order to characterise the D17MIT16 BAC DNA clone which is part of a 1200 kilobase DNA insert believed to contain mouse trypanotolerance genes, restriction endonucleases were used to digest the insert for restriction mapping, identification of DNA markers, sub cloning and sequencing. The D17MIT...

Trypanosoma congolense, which is responsible for most of animal trypanosomiasis 10 Africa, has a great diversity of variants. Differences occur between stocks from different geographical regions and also between stocks within the same area. In the present work molecular karyotyping was used to in...