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Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localisation of genes controlling resistance to trypanosomiasis in mice]Localisation of genes controlling resistance to trypanosomiasis in mice
Picozzi, K.Fèvre, Eric M.Odiit, M.Carrington, M.Eisler, M.C.Maudlin, I.[Sleeping sickness in Uganda: A thin line between two fatal diseases]Sleeping sickness in Uganda: A thin line between two fatal diseases
Welburn, S.C.Fèvre, Eric M.Coleman, P.G.Odiit, M.Maudlin, I.[Sleeping sickness: A tale of two diseases]Sleeping sickness: A tale of two diseases
Zoller, T.Fèvre, Eric M.Welburn, S.C.Odiit, M.Coleman, P.G.[Analysis of risk factors for T. brucei rhodesiense sleeping sickness within villages in south-east Uganda]Analysis of risk factors for T. brucei rhodesiense sleeping sickness within villages in south-east Uganda

This study aimed to provide the foundation for an integrative approach to the identification of the mechanisms underlying the response to infection with Trypanosoma congolense, and to identify pathways that have previously been overlooked. We undertook a large-scale gene expression analysis study...


Kierstein, S.Noyes, H.Naessens, JanNakamura, Y.Pritchard, J.Gibson, John P.Kemp, Stephen J.Brass, A.[Gene expression profiling in a mouse model for African trypanosomiasis]Gene expression profiling in a mouse model for African trypanosomiasis

Synthetic antimicrobial 9-mer peptides (designated as peptides A and B) designed on the basis of insect defensins and their effects on the growth of African trypanosomes were examined using two isolates of Trypanosoma congolense, IL1180 and IL3338, and two isolates of Trypanosoma brucei brucei, I...


Kitani, H.Naessens, JanKubo, M.Nakamura, Y.Iraqi, F.A.Gibson, John P.Yamakawa, M.[Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture]Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture

The mechanisms whereby trypanotolerant N'Dama cattle control infection with Trypanosoma congolense are unknown. Previous studies have suggested that the monocytes of N'Dama cattle are more highly activated during infection than those of trypanosus ceptible Boan cattle. However, we have recently r...


Taylor, K.Mertens, B.Lutje, V.Saya, R.[Trypanosoma congolense infection of trypanotolerant N'Dama (Bos taurus) cattle is associated with decreased secretion of nitric oxide by interferon-gamma-activated monocytes and increased transcription of interleukin-10]Trypanosoma congolense infection of trypanotolerant N'Dama (Bos taurus) cattle is associated with decreased secretion of nitric oxide by interferon-gamma-activated monocytes and increased transcription of interleukin-10

Interviews with all the households in the Agropastoral Zone (ZAP) of Yale, southern Burkina Faso, were conducted in 1994 and again in 1997 to assess the impacts of a tsetse control programme implemented from 1994, using insecticide-impregnated targets and pour-on treatments of all cattle with del...


Kamuanga, M.Sigue, H.Swallow, B.M.Bauer, B.D'Ieteren, G.D.M.[Farmers' perceptions of the impacts of tsetse and trypanosomosis control on livestock production: Evidence from southern Burkina Faso]Farmers' perceptions of the impacts of tsetse and trypanosomosis control on livestock production: Evidence from southern Burkina Faso

The membrane-associated form of the variable surface glycoprotein (mfVSG) from African trypanosomes is a potent macrophage activator capable of inducing production of tumor necrosis factor z (TNFalfa) in both bovine and murine models. Using a bovine model. we have re-investigated the hypothesis t...


Sileghem, M.R.Saya, R.Grab, D.J.Naessens, Jan[An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes]An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes

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