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A raíz del incremento a nivel mundial de la prevalencia de sobrepeso y obesidad tanto en adultos como en niños, con consecuencias en la salud pública, la obesidad se ha convertido en un blanco de estudio de diferentes grupos de investigación, lo que a su vez involucra el entendimiento del proceso...


González-Casanova, J.E.Cruz, S.L.P.Vivas, M.C.Rojas-Gómez, D.M.[Influence of endocrine disrupting chemicals on adipogénesis][Influencia de disruptores endocrinos medioambientales sobre la adipogénesis]Influencia de disruptores endocrinos medioambientales sobre la adipogénesis

Introduction: Morbid obesity generates a considerable decrease in expectations and quality of life, which causes increased levels of depression and anxiety. Objective: The purpose of this research was to determine the effects of a comprehensive treatment program on weight loss and anxiety and dep...


Cofre-Lizama, A.Delgado-Floody, P.Angulo-Díaz, P.Jerez-Mayorga, D.[Comprehensive eight-month intervention reduces weight and improves depression and anxiety levels in severe and morbid obesity][Intervención integral de ocho meses disminuye el peso y mejora los niveles de depresión y ansiedad en obesos severos y mórbidos]Intervención integral de ocho meses disminuye el peso y mejora los niveles de depresión y ansiedad en obesos severos y mórbidos

The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of ...


Lorca, M.Morales-Verdejo, C.Vásquez-Velásquez, D.Andrades-Lagos, J.Campanini-Salinas, J.Soto-Delgado, J.Recabarren-Gajardo, G.Mella, J.[Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles]Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles

The beta(3) adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective and high affinity ligands have been made. Currently, Mirabegron is the only availa...


Apablaza, G.Montoya, L.Morales-Verdejo, C.Mellado, M.Cuellar, M.Lagos, C.F.Soto-Delgado, J.Chung, H.Pessoa-Mahana, C.D.Mella, J.[2D-QSAR and 3D-QSAR/CoMSIA studies on a series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-phenylethan-1-ol with human β3-adrenergic activity]2D-QSAR and 3D-QSAR/CoMSIA studies on a series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-phenylethan-1-ol with human β3-adrenergic activity

Alteraciones en el desarrollo de la atención y la organización conductual pueden configurar cuadros clínicos como el trastorno déficit de atención (TDA) que puede estar acompañado o no de hiperactividad (TDAH), este último parece tener una relación directa con otros diagnósticos de tipo endocrino...


Torres, M.Bermúdez, V.Ortiz, R.Siguencia, W.Prieto, C.Añez, R.Martínez, M.S.Dávila, L.A.Rojas-Gómez, D.M.Salazar, J.González-Casanova, J.E.Guette, L.S.Guillén-Burgos, H.F.Kusmar, I.Roque, W.Rojas, E.Rojas, J.[FTO gene: Historic background and its relationship with chronic-degenerative diseases][Gene FTO: Aspectos históricos y su relación con enfermedades crónicas no comunicables]Gene FTO: Aspectos históricos y su relación con enfermedades crónicas no comunicables

Background: The evaluation of cardiorespiratory fitness (RCC) using maximal or peak oxygen consumption (VO2), requires a high level of effort in obese patients. We propose a method to evaluate RCC using constant and moderate loads, called VO2 kinetics (tau). Aim: To determine the relationship ...


Miranda, C.Ibacache, P.Opazo, E.Rojas, J.Cano, M.[Oxygen uptake kinetics to assess cardiorespiratory fitness in obese patients][Uso de la cinética del consumo de oxígeno para la evaluación de la capacidad cardiorrespiratoria en pacientes con obesidad]Uso de la cinética del consumo de oxígeno para la evaluación de la capacidad cardiorrespiratoria en pacientes con obesidad

Bariatric surgery is considered the most effective treatment for severe obesity and its benefits include improvement in medical comorbidities. However, a higher rate of suicides after this type of surgery has been reported. We performed a literature review on the subject, and concluded that the m...

Bariatric surgery is considered the most effective treatment for severe obesity and its benefits include improvement in medical comorbidities. However, a higher rate of suicides after this type of surgery has been reported. We performed a literature review on the subject, and concluded that the m...


Roizblatt, ARoizblatt, DSoto-Aguilar, BF[Suicide risk after bariatric surgery, Suicide risk after bariatric surgery][Suicidio y cirugía bariátrica: un estudio de la evidencia]Suicidio y cirugía bariátrica: un estudio de la evidencia

Chile has implemented several strategies to decrease the burden of obesity and chronic diseases. The Food Labeling and Advertising Law (Law 20.606) requires a front-of-package "high in" warning label when energy and nutrients of concern (ENC) (total sugar, saturated fats, sodium) exceed establish...


Background: Overweight and obesity are significant public health concerns that are prevalent in younger age cohorts. Preventive or therapeutic interventions are difficult to implement and maintain over time. On the other hand, the majority of adolescents in the United States have a smartphone, re...


Caamaño Navarrete, FelipeAlarcon Hormazabal, ManuelDelgado Floody, Pedro[LEVELS OF OBESITY, METABOLIC PROFILE, CONSUMPTION OF TABACO AND BLOOD PRESSURE IN SEDENTARY YOUTHS]LEVELS OF OBESITY, METABOLIC PROFILE, CONSUMPTION OF TABACO AND BLOOD PRESSURE IN SEDENTARY YOUTHS

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